多点矩阵扫描激光与多波长激光治疗糖尿病视网膜病变合并黄斑水肿效果比较

发布时间：2018-05-08 13:45

本文选题：糖尿病视网膜病变 + 黄斑水肿　；参考：《山东医药》2017年09期

【摘要】：目的对比577 nm多点扫描矩阵激光与多波长激光治疗糖尿病视网膜病变(SNPDR)合并黄斑水肿的效果。方法将SNPDR合并黄斑水肿的68例(76只眼)患者随机分为两组,A组36只眼采用577 nm多点扫描矩阵激光分2次完成全视网膜激光光凝(PRP),单点模式行黄斑区格栅样光凝;B组40只眼采用多波长扫描激光分4次完成PRP,黄光行黄斑区格栅样光凝。分别于治疗前和治疗后1周、1个月、3个月时采用ETDRS视力表检测两组最佳矫正视力(BCVA)、光学相干断层扫描(OCT)检测黄斑中心凹厚度(CMT)和视乳头旁视神经纤维层(RNFL)厚度。结果两组BCVA于激光治疗后缓慢上升,治疗3个月时与治疗前相比,P均0.05;治疗1周、1个月、3个月时两组BCVA比较,P均0.05。两组CMT于治疗1个月时较治疗前均减少(P0.05),3个月时较治疗前略增加(P0.05),治疗1周、1个月、3个月时两组间CMT比较,P均0.05。治疗后A组平均RNFL厚度未见明显变化,而B组平均RNFL厚度于治疗3个月时与治疗前相比增加(P0.05),两组3个月时RNFL厚度比较,P0.05。结论 577 nm多点扫描矩阵激光与多波长激光对SNPDR合并黄斑水肿患者的治疗效果相当,多波长激光在治疗后短期可能引起视神经纤维层厚度增加。
[Abstract]:Objective to compare the efficacy of 577 nm multipoint scanning matrix laser and multiwavelength laser in the treatment of diabetic retinopathy with macular edema. Methods Sixty-eight patients with macular edema in 68 patients with macular edema were randomly divided into two groups: group A (36 eyes) and group A (36 eyes) were treated with 577nm multipoint scanning matrix laser. PRP was performed in 40 eyes by multi-wavelength scanning laser in 4 times. Before treatment and 1 week, 1 month and 3 months after treatment, ETDRS visual acuity chart was used to detect the thickness of macular foveal thickness and parapapillary optic nerve fiber layer, respectively. Optical coherence tomography (Oct) was used to detect the thickness of macular foveal thickness. Results the BCVA of the two groups increased slowly after laser treatment (P < 0.05) at 3 months after laser treatment, and at 1 week, 1 month and 3 months after treatment, the BCVA of both groups was 0.05. The CMT of the two groups decreased at 1 month after treatment compared with that before treatment, and increased slightly at 3 months after treatment. The comparison of CMT between the two groups at 1 week, 1 month and 3 months was 0.05. After treatment, the average RNFL thickness of group A did not change significantly, but the average thickness of RNFL in group B increased P0.05 after 3 months of treatment, and the thickness of RNFL in group B was significantly higher than that in group B at 3 months after treatment, and the thickness of RNFL in group B was significantly higher than that in group B at 3 months after treatment. Conclusion 577nm multipoint scanning matrix laser and multiwavelength laser have the same effect on SNPDR patients with macular edema. The thickness of optic nerve fiber layer may be increased in the short term after treatment with multiwavelength laser.
【作者单位】：第四军医大学唐都医院;
【基金】：国家自然科学基金青年项目(81200617) 陕西省自然科学基金项目(2012JM4055)
【分类号】：R587.2;R779.63

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