西宁地区不同季节下人群血清中维生素D水平和骨密度的关系

发布时间：2018-05-08 22:33

本文选题：(OH)D + 甲状旁腺激素　；参考：《广东医学》2017年17期

【摘要】：目的研究西宁不同季节人群血清维生素D水平及其与骨密度(BMD)的关系。方法调查统计测定1 600例成年人的血清甲状旁腺激素(PTH)、25羟维生素[25(OH)D]、BMD数值,并且进行分析。对1 600例成年人进行1年的跟踪观察,分别在3、6、9和12月中旬测得不同季度下的数据值,并进行统计分析。根据国际骨质疏松基金会的维生素D水平的判定标准,根据受检测者的维生素D水平,分为正常、不足、缺乏和严重缺乏4个组。在早上8:00—9:00之间,所有受检测者空腹采集静脉血5 mL,使用自动生化分析仪和全自动电化学免疫发光分析仪进行检测。结果不同季节,血清25(OH)D的水平差异有统计学意义(P0.05);血清25(OH)D和PTH有明显的相关性(P0.05)。在不同组之间血清钙的平均水平比较差异有统计学意义(P0.05);4组受检测者之间身高、年龄、体重的差异有统计学意义(P0.05)。根据4组的血清25(OH)D和BMD测定值,发现维生素D严重缺乏组、缺乏组和不足组的腰椎的BMD值均低于维生素D正常组,差异有统计学意义(P0.05)。结论缺乏甚至严重缺乏维生素D是人群之中比较普遍的现象,应该高度重视,提出改善的方法,从而降低由于维生素D缺乏而导致的疾病的发病率。
[Abstract]:Objective to study the relationship between serum vitamin D level and bone mineral density (BMD) in Xining population in different seasons. Methods Serum parathyroid hormone (PTH) 25 hydroxyvitamin [25(OH)D] was measured and analyzed in 1 600 adults. 1 600 adults were followed up for 1 year. The data were measured in different quarters in 3 / 6 / 9 and 12 / 12, respectively, and were statistically analyzed. According to the criteria of vitamin D level of the International Osteoporosis Foundation, the subjects were divided into four groups: normal, insufficient, deficient and severely deficient. Between 8: 00-9: 00 in the morning, all the subjects collected 5 mL of venous blood on an empty stomach and detected it by automatic biochemical analyzer and automatic electrochemiluminescence analyzer. Results the levels of serum 25(OH)D were significantly different in different seasons, and there was a significant correlation between serum 25(OH)D and PTH. There was significant difference in the average serum calcium level among different groups. There were significant differences in height, age and weight among the four groups. According to the determination of serum 25(OH)D and BMD in the four groups, it was found that the BMD values of the lumbar vertebrae in the severe vitamin D deficiency group, the deficiency group and the deficiency group were lower than those in the normal vitamin D group, and the difference was statistically significant (P 0.05). Conclusion deficiency or even severe deficiency of vitamin D is a common phenomenon in the population, which should be paid more attention to and put forward the methods to improve it so as to reduce the incidence of diseases caused by vitamin D deficiency.
【作者单位】：青海省人民医院内分泌科;
【基金】：青海省2015年卫生计生指导性科研课题(编号:15)
【分类号】：R580

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