痛风性关节炎骨质疏松患者血清LEP、OPG与IL-6、TNF-α相关性研究

发布时间：2018-05-09 22:04

本文选题：关节炎 + 痛风性　；参考：《重庆医学》2017年33期

【摘要】：目的分析痛风性关节炎骨质疏松患者血清瘦素(LEP)、骨保护素(OPG)与炎症因子白细胞介素(IL-6)、肿瘤坏死因子α(TNF-α)相关性。方法选择痛风性关节炎患者48例为研究对象(GA组),其中伴有骨质疏松19例(OP组),不伴有骨质疏松29例(非OP组),另选择健康体检者45例为对照。以双能X线骨密度吸收仪测定骨密度,ELISA检测血清LEP、OPG及IL-6、TNF-α水平并分析相关性。结果 GA组患者骨质疏松发生率39.6%明显高于对照组的13.3%(P=0.004),各部位骨密度明显低于对照组(P0.05)。与对照组及非OP组相比,OP组患者血清LEP水平明显升高,OPG水平明显降低,差异有统计学意义(P0.05)。非OP组患者血清LEP水平明显高于对照组(P0.05),但OPG水平差异无统计学意义(P0.05)。OP组患者血清IL-6、TNF-α水平明显高于非OP组及对照组(P0.05),非OP组明显高于对照组(P0.05)。OP组患者血清LEP与IL-6、TNF-α呈正相关(P0.05),血清OPG与IL-6、TNF-α呈负相关(P0.05)。结论痛风性关节炎伴发骨质疏松患者血清LEP、OPG呈异常变化,其与IL-6、TNF-α有一定相关性。
[Abstract]:Objective to analyze the relationship between serum leptin (leptin), osteoprotegerin (OPG) and inflammatory factor interleukin-6 (IL-6), tumor necrosis factor 伪 (TNF- 伪) in patients with gouty arthritis and osteoporosis. Methods A total of 48 patients with gouty arthritis were studied in GA group, including 19 patients with osteoporosis in op group, 29 patients without osteoporosis (non-op group) and 45 healthy persons as control. The serum levels of LEP- OPG and IL-6 TNF- 伪 were measured by dual-energy X-ray absorptiometry and the correlation was analyzed. Results the incidence of osteoporosis in GA group was significantly higher than that in control group (39.6%), and the bone mineral density (BMD) in all parts of GA group was significantly lower than that in control group (P 0.05). Compared with the control group and the non-op group, the serum LEP level in the op group was significantly higher than that in the control group and the non-op group, and the difference was statistically significant (P 0.05). The level of serum LEP in non-op group was significantly higher than that in control group (P0.05), but there was no significant difference in OPG level. The level of IL-6TNF- 伪 in patients with non-op group was significantly higher than that in non-op group and control group (P0.05A). The level of serum LEP and IL-6 TNF- 伪 in non-op group was significantly higher than that in control group (P0.05). The level of IL-6 TNF- 伪 in op group was significantly higher than that in control group (P 0.05). There was a positive correlation between serum OPG and IL-6 TNF- 伪, and a negative correlation between serum OPG and IL-6 TNF- 伪. Conclusion the serum levels of LEP- OPG in patients with gouty arthritis complicated with osteoporosis are abnormal, which is related to IL-6 TNF- 伪.
【作者单位】：四川省遂宁市中心医院检验科;
【基金】：四川省卫生和计划生育委员会科研课题(17PJ067)
【分类号】：R580;R589.7

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