Th17细胞和Treg细胞比例失衡在AS发展中作用的研究进展

发布时间：2018-05-10 10:52

本文选题：强直性脊柱炎 + Th细胞　；参考：《现代免疫学》2016年01期

【摘要】：在强制性脊柱炎(ankylosing spondylitis,AS)发病机制的诸多假设中,免疫细胞格局失调被认为是一个重要机制。Th17细胞和Treg细胞是CD4+T细胞的两个亚群,对炎症分别起着促进和抑制的作用。诸多研究提示,Th17细胞和Treg细胞数量及相关细胞因子在AS患者外周血中与健康者有差别,其比例失衡在AS的发展中有重要作用,具体机制仍不清楚。本文介绍了近年来Th17和Treg细胞及其比例失衡在AS发展中作用的研究进展。
[Abstract]:In many hypotheses of the pathogenesis of mandatory spondylitis, immune cell pattern disorder is considered to be an important mechanism. Th17 cells and Treg cells are two subsets of CD4 T cells, which play a role in promoting and inhibiting inflammation, respectively. Many studies suggest that the number of Th17 cells and Treg cells and related cytokines are different in the peripheral blood of as patients, and the imbalance of the ratio of Th17 cells and Treg cells plays an important role in the development of as, and the specific mechanism is still unclear. In this paper, the research progress of Th17 and Treg cells and their proportion imbalance in the development of as are reviewed.
【作者单位】：上海交通大学医学院免疫与微生物系;
【基金】：上海市科委基础研发重点项目(11JC1411602) 上海市教委科研创新重点项目(12ZZ1103) 国家自然科学基金(81373208) 上海交通大学医学院2013级PBL项目
【分类号】：R593.23

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