非布司他对比别嘌醇治疗高尿酸血症的疗效和安全性评价

发布时间：2018-05-10 13:15

本文选题：非布司他 + 高尿酸血症　；参考：《南昌大学》2015年硕士论文

【摘要】：目的:系统评价非布司他对比别嘌醇治疗高尿酸血症的疗效与安全性。方法:检索Pub Med、MEDLINE、ISI Web of knowledge、CNKI、CBM、万方等数据平台,检索年限从2004年9月至2014年9月,纳入非布司他及别嘌醇治疗高尿酸血症的随机对照试验,进行质量评价,运用Revman5.0软件对两药治疗高尿酸血症的疗效及安全性进行Meta分析。结果:共纳入7篇文献,截止至最后随访,非布司他组血清尿酸值达标的患者比例明显高于别嘌醇组(69.5%vs 43.6%;OR=3.38;95%CI,1.96-5.81;P0.01)。亚组分析显示:非布司他40mg/d比别嘌醇100~300mg/d有更高比例的患者达到目标血清尿酸值(50.6%vs 46.1%;OR=1.22;95%CI,1.02-1.45;P=0.03)。随着非布司他剂量增加至(80、120mg/d),达到目标血清尿酸值的患者比例明显升高(分别为72.8%、82.0%)在副作用方面非布司他和别嘌醇没有明显的差距。结论:非布司他(40~120mg/d)比别嘌醇(100~300mg/d)降尿酸效果更好。安全性方面非布司他和别嘌醇相似。
[Abstract]:Objective: to evaluate the efficacy and safety of nonbuflast compared with allopurinol in the treatment of hyperuricemia. Methods: the data platforms such as Pub Medine MEDLINEISI Web of knowledge CNKICBM were searched. The retrieval period was from September 2004 to September 2014, and the quality evaluation was carried out in a randomized controlled trial of the treatment of hyperuricemia with non-Budestar and allopurinol. The efficacy and safety of two drugs in the treatment of hyperuricemia were analyzed by Meta software Revman5.0. Results: by the end of the last follow-up, the proportion of patients in the non-Budesta group who had met the level of serum uric acid was significantly higher than that in the allopurinol group (69.5 vs 43.6%). Subgroup analysis showed that a higher proportion of patients with 40mg/d than allopurinol 100~300mg/d reached the target serum uric acid value of 50.6 vs 46.1%. There was no significant difference in side effects between nonbusultan and allopurinol in side effects with the increase of the dose of non-busultan to 80120 mg / d, the proportion of patients who reached the target serum uric acid level increased significantly (72.8% 82.0, respectively). Conclusion: compared with allopurinol (100 mg / d), busultadine (40mg / d) is more effective than allopurinol (300mg / d) in reducing uric acid. In terms of safety, it is similar to allopurinol.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R589.7

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