边缘性锌缺乏对大鼠肥胖的影响

发布时间：2018-05-11 06:46

本文选题：锌缺乏 + 体脂　；参考：《卫生研究》2017年03期

【摘要】：目的观察边缘性锌缺乏对大鼠肥胖的影响。方法 SPF级成年雄性SD大鼠32只,随机分为4组,低锌组喂饲含6 mg/kg锌的边缘性锌缺乏饲料,中锌组喂饲含10 mg/kg锌的边缘性锌缺乏饲料,低锌对饲组和对照组喂饲正常锌含量的AIN-93M饲料。喂养6周后,处死动物。测血锌、血脂、血清瘦素含量,肝脏总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平。结果低锌组大鼠第5周起血锌含量明显低于低锌对饲组和对照组(P0.05),成功建立边缘性缺锌模型。第6周时,低锌组大鼠脂体比明显高于低锌对饲组和对照组(P0.05);低锌组和中锌组大鼠肝脏MDA含量明显高于对照组(P0.05);低锌组和中锌组大鼠肝脏TAOC、SOD水平明显低于对照组(P0.05)。结论边缘性锌缺乏可增加肥胖发生的风险,缺锌组大鼠体内氧化应激升高可能是边缘性锌缺乏增加肥胖风险的主要原因。
[Abstract]:Objective to observe the effect of marginal zinc deficiency on obesity in rats. Methods Thirty-two adult male SD rats of SPF grade were randomly divided into 4 groups. The low zinc group was fed with marginal zinc deficiency diet containing 6 mg/kg zinc, while the middle zinc group was fed with 10 mg/kg zinc borderline zinc deficiency diet. Low zinc group and control group were fed with AIN-93M diet with normal zinc content. After 6 weeks of feeding, the animals were killed. The levels of serum zinc, serum lipid, serum leptin, total antioxidant capacity of liver, superoxide dismutase (SOD) and malondialdehyde (MDA) were measured. Results the serum zinc content in the low zinc group was significantly lower than that in the low zinc feeding group and the control group from the 5th week, and the marginal zinc deficiency model was successfully established. At the 6th week, the lipid body ratio of the rats in the low zinc group was significantly higher than that in the low zinc feeding group and the control group (P 0.05), the MDA content in the liver of the low zinc group and the middle zinc group was significantly higher than that of the control group (P 0.05), and the level of TAOCU SOD in the liver of the low zinc group and the middle zinc group was significantly lower than that of the control group (P 0.05). Conclusion Peripheral zinc deficiency can increase the risk of obesity. The increase of oxidative stress in rats with zinc deficiency may be the main reason for increasing the risk of obesity.
【作者单位】：中国疾病预防控制中心营养与健康所国家卫生计生委微量元素营养重点实验室;
【基金】：国家自然科学基金(No.81273073)
【分类号】：R589.2

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