天麦消渴片治疗2型糖尿病的临床效果及安全性观察

发布时间：2018-05-11 20:49

本文选题：型糖尿病 + 天麦消渴片　；参考：《山东医药》2016年12期

【摘要】：目的探讨天麦消渴片治疗2型糖尿病(T2DM)的临床效果及安全性。方法 132例新诊断、未治疗的T2DM患者随机分为天麦消渴片组68例及吡格列酮组64例,两组均给予饮食、运动及二甲双胍等治疗,在此基础上,天麦消渴片组口服天麦消渴片、吡格列酮组口服吡格列酮,均连续治疗12周。治疗前后分别测定两组空腹血糖(FPG)、餐后2 h血糖(2 h PG)、空腹胰岛素(FINS)、空腹C肽(FCP)、餐后2 h胰岛素(2 h INS)、餐后2 h C肽(2 h CP)、糖化血红蛋白(Hb A1c),及血脂、血压、腰臀比(WHR)、肝功能、肾功能,计算胰岛素抵抗指数(HCMA-IR)等。结果天麦消渴片组治疗后WHR及FPG、2 h PG、Hb A1c、FINS、HOMA-IR水平均较治疗前降低(P0.05或0.01),HOMA-β较治疗前升高(P0.05);吡咯列酮组治疗后FPG、2 h PG、Hb A1c、FCP、HOMA-IR水平均较治疗前降低(P0.05或0.01)。天麦消渴片组治疗后FPG、Hb A1c、HOMA-IR均低于吡格列酮组(P均0.05)。两组治疗后均未见明显不良反应。结论天麦消渴片可改善初发T2DM患者胰岛素敏感性,降低血糖、WHR和Hb A1c水平,且用药安全。
[Abstract]:Objective to evaluate the efficacy and safety of Tianmaixiaoke tablet in the treatment of type 2 diabetes mellitus (T 2 DM). Methods 132 newly diagnosed and untreated T2DM patients were randomly divided into Tianmaixiaoke tablet group (n = 68) and pioglitazone group (n = 64). Both groups were treated with diet, exercise and metformin. Pioglitazone group was treated with pioglitazone for 12 weeks. Before and after treatment, fasting blood glucose (FPGN), postprandial blood glucose (2 h), plasma glucose (2 h), fasting insulin (FINSN), fasting C-peptide (FCPP), insulin (2 h), C-peptide (2 h), hemoglobin (HbA1c), blood lipids, blood pressure, waist-to-hip ratio (WHR), liver function, liver function were measured before and after treatment. Renal function, calculate insulin resistance index (HCMA-IRI) and so on. Results the levels of WHR and PGHbA1cFCPHOMA-IR in Tianmaixiaoke tablet group were significantly lower than those before treatment (P0.05 or 0.01), and the levels of PGHbA1cFCPHOMA-IR in pyrrolidone group were significantly lower than those before treatment (P0.05 or 0.01). In Tianmaixiaoke tablet group, the HOMA-IR of FPGN HbA1cFI was lower than that of pioglitazone group (P < 0.05). There was no obvious adverse reaction after treatment in both groups. Conclusion Tianmaixiaoke tablet can improve the insulin sensitivity, decrease the levels of blood glucose and HbA1c in patients with T2DM, and it is safe to use it.
【作者单位】：中国医科大学附属第一医院;
【基金】：辽宁省科学事业公益研究基金资助项目(2014001013)
【分类号】：R587.1

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