绝经后女性2型糖尿病患者骨密度及骨标志物水平研究

发布时间：2018-05-12 13:07

本文选题：型糖尿病 + 绝经后女性　；参考：《中国骨质疏松杂志》2017年02期

【摘要】：目的探讨绝经后女性2型糖尿病患者的骨密度及骨标志物水平。方法选择2014年12月~2016年3月在309医院骨内科住院的绝经后女性患者128例,其中2型糖尿病者60例为研究组,年龄50-69岁,平均年龄60.8岁,无糖尿病者68例为对照组,年龄50-69岁,平均年龄59.8岁,采用美国好乐杰公司双光能骨密度仪测量所有患者腰椎L2-L4和左侧股骨近端及全髋骨密度,并测定其身高、体重、体重指数(BMI),记录其入院时生化指标如血脂,血钙、磷、镁、空腹血糖情况,采用酶联免疫吸附法测定各组的B-ALP、CTX、PINP、25羟维生素D的水平,比较两组间骨密度值、生化指标及骨标志物水平是否存在统计学差异。结果两组间一般情况如年龄、身高、体重、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血镁、血脂水平无统计学差异,两组髋部及腰1-4椎体骨密度水平、25羟维生素D及PTH无统计学差异。观察组空腹血糖、血钙水平、骨代谢标志物CTX高于对照组,而OC、ALP低于对照组,差异具有统计学意义。结论绝经后2型糖尿病妇女骨转换标志物异常,可能是预测糖尿病性骨质疏松的一个标志。
[Abstract]:Objective to investigate the bone mineral density (BMD) and bone markers in postmenopausal women with type 2 diabetes. Methods 128 postmenopausal women hospitalized in the Department of Osteology, 309 Hospital from December 2014 to March 2016, including 60 patients with type 2 diabetes mellitus, aged 50-69 years, with an average age of 60.8 years, and 68 patients without diabetes mellitus as control group, aged 50-69 years, were selected. The average age was 59.8 years. The bone density of lumbar vertebrae, proximal femur and total hip of all patients were measured by dual optical energy BMD, and their height, body mass index (BMI) and blood lipid at admission were measured. Serum calcium, phosphorus, magnesium and fasting blood glucose were measured by enzyme-linked immunosorbent assay (Elisa). The BMD, biochemical indexes and bone markers were compared between the two groups. Results there was no significant difference between the two groups in general conditions such as age, height, weight, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, serum magnesium, and blood lipid levels. There was no significant difference in bone mineral density (BMD) of hip and lumbar 1-4 vertebrae between the two groups. The fasting blood glucose, serum calcium level and bone metabolism marker CTX in the observation group were higher than those in the control group, while OCU ALP was lower than that in the control group, the difference was statistically significant. Conclusion abnormal bone turnover markers in postmenopausal women with type 2 diabetes may be a predictor of diabetic osteoporosis.
【作者单位】：解放军第309医院全军骨科中心骨内科;
【基金】：全军十二五课题:军队中老年干部骨质疏松筛查及防治研究(CWS11J169)
【分类号】：R587.2;R580

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