糖尿病视网膜病变患者血糖及凝血指标的变化

发布时间：2018-05-12 18:53

本文选题：糖尿病 + 视网膜病变　；参考：《中国现代医学杂志》2017年12期

【摘要】：目的观察糖尿病视网膜病变患者血糖指标、凝血因子及血小板参数的变化,探讨其在糖尿病视网膜病变中的临床意义。方法选取2014年3月-2016年10月在海南省海口市人民医院诊断为糖尿病视网膜病变患者102例作为糖尿病视网膜病变组,糖尿病患者102例作为糖尿病组,健康体检者102例作为对照组。测定3组患者血糖指标、凝血因子及血小板参数。结果糖尿病视网膜病变组糖尿病病程长于糖尿病组(P0.05);糖尿病视网膜病变组空腹血糖(FPG)、糖化血红蛋白(Hb A1c)高于糖尿病组和对照组(P0.05),糖尿病组FPG、Hb A1c高于对照组(P0.05);糖尿病视网膜病变组和糖尿病组纤维蛋白原含量(FIB)、凝血酶原百分活动度(PT%)高于对照组(P0.05),糖尿病视网膜病变组FIB高于糖尿病组(P0.05);糖尿病视网膜病变组和糖尿病组大型血小板比率(P-LCR)、平均血小板体积(MPV)、体积分布宽度(PDW)高于对照组(P0.05),糖尿病视网膜病变组P-LCR、MPV、PDW高于糖尿病组(P0.05)。结论糖尿病视网膜病变患者血糖指标、凝血因子及血小板参数存在异常,糖尿病视网膜病变发病可能与血糖、凝血因子及血小板参数变化有关。
[Abstract]:Objective to observe the changes of blood glucose, coagulation factor and platelet parameters in patients with diabetic retinopathy (DM) and to explore its clinical significance in diabetic retinopathy. Methods from March 2014 to October 2016, 102 patients with diabetic retinopathy were selected as diabetic retinopathy group, 102 diabetic patients as diabetic group and 102 healthy persons as control group in Haikou people's Hospital of Hainan Province from March 2014 to October 2016. Blood glucose index, coagulation factor and platelet parameters were measured in 3 groups. Results the course of diabetes in the diabetic retinopathy group was longer than that in the diabetic group, and the fasting blood glucose and HbA1c in the diabetic retinopathy group were higher than those in the diabetic group and the control group (P0.05C), and the level of FPGnHbA1c in the diabetic group was higher than that in the control group (P0.05C), and that in the diabetic retinopathy group was higher than that in the control group (P 0.05). The content of fibrinogen and prothrombin activity of diabetic retinopathy group and diabetic group were higher than that of control group (P 0.05), the FIB of diabetic retinopathy group was higher than that of diabetic group (P 0.05), and the large blood level of diabetic retinopathy group and diabetic group was higher than that of diabetic group. The mean platelet volume (MPV) and the volume distribution width (PDW) were higher than those in the control group (P 0.05), and that in the diabetic retinopathy group was higher than that in the diabetic group (P 0.05). Conclusion there are abnormal blood glucose indexes, coagulation factors and platelet parameters in patients with diabetic retinopathy. The pathogenesis of diabetic retinopathy may be related to the changes of blood glucose, coagulation factors and platelet parameters.
【作者单位】：海南省海口市人民医院(中南大学湘雅医学院附属海口医院)眼科;海南医学院第一附属医院眼科;海南省海口市人民医院(中南大学湘雅医学院附属海口医院)内分泌科;
【分类号】：R587.2;R774.1

【相似文献】