甲状腺体积和结节与硒营养状况的相关性研究

发布时间：2018-05-13 00:12

本文选题：硒 + 碘　；参考：《中华临床医师杂志(电子版)》2017年10期

【摘要】：目的探究本地区甲状腺体积与硒的相关性及硒营养水平是否是甲状腺肿大及甲状腺结节的危险因素。方法本文使用分层抽样的方法调查了年满18周岁且在山西太原居住5年以上的居民,共计1 470人参加了调查,内容包括问卷调查、体格检查、甲状腺功能、甲状腺超声、尿碘及血硒水平,其中1 339人满足条件。本文使用了参数及非参检验分析数据。结果调查人群中尿碘的中位数是:216.4μg/L(四分位数区间:139.9μg/L,303.6μg/L),表明碘的营养情况处于超足量状态;血硒的中位数:78.21μg/L(四分位数区间:58.46μg/L,128.77μg/L);甲状腺体积的中位数7.51 ml(四分位数区间5.90 ml,9.39 ml);血硒浓度与年龄呈负相关(r=-0.088,P=0.001),与BMI、TSH不相关(r=-0.007、P=0.801;r=-0.051、P=0.063);在线性回归分析中甲状腺体积与血硒无显著相关(β=-0.007,P=0.367);硒在有无甲状腺肿大中差异并不显著(P=0.278,OR=1.173);硒在有无甲状腺结节中差异也并不显著(P=0.399,OR=1.073)。结论硒不影响甲状腺肿大的发生,也不是甲状腺结节的影响因素。
[Abstract]:Objective to investigate the correlation between thyroid volume and selenium and whether selenium nutrition is a risk factor for thyroid enlargement and thyroid nodule. Methods stratified sampling was used to investigate the residents who were over 18 years old and lived in Taiyuan, Shanxi province for more than 5 years. A total of 1,470 people participated in the survey, including questionnaire, physical examination, thyroid function, thyroid ultrasound, and so on. Urine iodine and blood selenium levels, of which 1 339 met the condition. Parameters and non-parametric test data are used in this paper. Results the median of urinary iodine in the investigated population was 1: 216.4 渭 g / L (quartile range: 139.9 渭 g / L = 303.6 渭 g / L). The median of blood selenium was 78.21 渭 g / L (quartile: 58.46 渭 g / L = 128.77 渭 g / L); the median of thyroid volume was 7.51 ml (quartile = 5.90 ml ~ 9.39 ml / L); there was a negative correlation between serum selenium concentration and age and no correlation between serum selenium concentration and BMITSH was 0.801r-0.051g / L; in linear regression analysis, there was no correlation between thyroid volume and serum selenium. There was no significant difference in selenium in the presence or absence of thyroidomegaly, and there was no significant difference in selenium in thyroid nodule with or without thyroid nodules, and there was no significant difference in selenium with or without thyroid nodules. Conclusion selenium does not affect the occurrence of goiter and is not a factor of thyroid nodule.
【作者单位】：山西医科大学第一医院内分泌科;
【基金】：公益性行业科研专项(201402005) 中华医学会临床医学科研专项基金(15010010589) 山西省自然科学基金(2014011043-4)
【分类号】：R581

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