血清急性淀粉样蛋白A水平与白塞病活动度的相关性研究

发布时间：2018-05-15 20:19

本文选题：血清淀粉样蛋白A + 白塞病　；参考：《上海交通大学学报(医学版)》2017年07期

【摘要】：目的·评估血清急性淀粉样蛋白A(A-SAA)与白塞病(BD)活动度的相关性。方法·收集活动期BD(n=40)、缓解期BD(n=15)、大动脉炎(TA,n=12)、类风湿关节炎(RA,n=25)、系统性红斑狼疮(SLE,n=25)患者与健康对照(HD,n=15)的血清,分组比较不同患者的A-SAA、血沉(ESR)和C反应蛋白(CRP)的水平。分析A-SAA与国际白塞病学会(ISBD)疾病活动指数的相关性以及A-SAA与其相关下游分子IL-8的相关性。结果·A-SAA水平在活动期BD患者中异常升高[(115.70±87.78)mg/L],在RA及TA患者中也升高,分别为(68.72±61.50)mg/L和(96.25±87.41)mg/L;SLE患者中未见其升高。A-SAA与ISBD指数及血清IL-8水平相关。结论·A-SAA可作为评价BD活动度的检测指标之一。
[Abstract]:Objective to evaluate the correlation between serum acute amyloid A A SAA and BDD activity in Behcet's disease. Methods the serum levels of A-SAA, ESR) and C-reactive protein (CRP) were collected from patients with active stage BDN 40, remission of BDN 15, TAN 12, rheumatoid arthritis (RA) 25, systemic lupus erythematosus (SLEN) 25) and healthy controls (HDN 15). The serum levels of A-SAA, ESR and C-reactive protein (CRP) were compared in different patients. To analyze the correlation between A-SAA and ISBD disease activity index and the correlation between A-SAA and its downstream molecule IL-8. Results the level of A-SAA was increased abnormally in active BD patients [115.70 卤87.78)mg/L], and was also increased in RA and TA patients (68.72 卤61.50)mg/L and 96.25 卤87.41 mg / L, respectively). There was no correlation between A-SAA and ISBD index and serum IL-8 level. Conclusion A-SAA can be used as an index to evaluate the activity of BD.
【作者单位】：上海交通大学医学院附属仁济医院风湿科;
【基金】：国家自然科学基金(30972744)~~
【分类号】：R597.9

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