血尿酸水平与某干部人群发生慢性肾功能不全风险的相关性研究——以人群为基础的前瞻性研究

发布时间：2018-05-16 04:09

本文选题：高尿酸血症 + 慢性肾功能不全　；参考：《中国糖尿病杂志》2016年02期

【摘要】：目的观察血尿酸(SUA)与发生慢性肾功能不全(CRF)风险的相关性。方法选取2009年3月于我院健康查体中显示血肌酐(Scr)水平正常,且完成3年随访者1181名为研究对象。根据SUA水平分为C1(360μmol/L)组726例,C2(360~420μmol/L)组253例,C3(420~480μmol/L)组123例及C4(480μmol/L)组79例。比较各组CRF发病情况,并分析发生CRF的危险因素。结果与C1组比较,其他各组TC[(4.91±0.93)vs(5.81±1.01),(5.28±0.83),(5.25±1.22)mmol/L]和TG[(1.11±0.58)vs(2.97±1.06),(2.13±1.26),(1.65±1.19)mmol/L]升高(P0.05)。男性新发CRF患者在C1~C4组中所占比例分别为4.47%、12.13%、13.31%和14.72%;女性分别为2.17%、4.96%、18.21%和36.43%。多因素Logistic回归分析结果显示,校正年龄、BMI、SBP、DBP等因素影响后,SUA升高是CRF发病的独立危险因素。结论 SUA升高是该研究中某干部人群发生CRF的独立危险因素。
[Abstract]:Objective to investigate the relationship between serum uric acid (UAA) and the risk of chronic renal insufficiency (CRF). Methods 1181 patients who showed normal creatinine (SCR) level in our health examination in March 2009 and completed 3 years follow-up were selected as the study subjects. According to the SUA level, 726 cases of C2C2C360,420 渭 mol / L) group were divided into two groups according to the level of SUA: 123 cases of C3O42020 渭 mol / L group and 79 cases of C44-480 渭 mol / L group. The incidence of CRF in each group was compared and the risk factors of CRF were analyzed. Results compared with C1 group, TC (4.91 卤0.93)vs(5.81 卤1.01) and TG (1.11 卤0.58)vs(2.97 卤1.06 卤1.65 卤1.19)mmol/L) were significantly increased in other groups (P 0.05). The percentage of newly diagnosed CRF patients in the C1~C4 group was 4.47 / 12.1313.31% and 14.72% respectively, and that in the female was 2.174.96% and 18.21% and 36.43%, respectively. Multivariate Logistic regression analysis showed that the increase of SUA was an independent risk factor of CRF. Conclusion elevated SUA is an independent risk factor for the occurrence of CRF in a cadre population in this study.
【作者单位】：解放军第305医院内分泌科;解放军第305医院体检中心;
【分类号】：R589.7

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