依帕司他、α-硫辛酸联合胰岛素泵强化治疗对老年糖尿病周围神经病变患者氧化应激反应的影响

发布时间：2018-05-17 05:07

本文选题：依帕司他 + α-硫辛酸　；参考：《中国老年学杂志》2017年17期

【摘要】：目的探讨依帕司他、α-硫辛酸联合胰岛素泵强化治疗对老年糖尿病周围神经病变患者氧化应激反应的影响。方法 2014年8月至2016年6月该院接受治疗的120例老年糖尿病周围神经病变患者,根据随机数表法分为对照组及观察组各60例。对照组采用α-硫辛酸联合胰岛素泵强化治疗,观察组采用依帕司他、α-硫辛酸联合胰岛素泵强化治疗。比较两组治疗前后血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平、神经传导情况,并评价两组临床疗效。结果与治疗前比较,两组血清SOD、GSH-Px水平、正中神经、腓总神经的运动与感觉传导速度均明显上升,且观察组上升幅度大于对照组(P0.05);观察组临床总有效率明显高于对照组(P0.05)。结论采用依帕司他、α-硫辛酸联合胰岛素泵强化治疗老年糖尿病周围神经病变可显著提高临床疗效,改善氧化应激反应,提高神经传导速度,促进患者身体恢复,治疗优势显著。
[Abstract]:Objective to investigate the effect of epalrestat 伪-lipoic acid combined with insulin pump intensive therapy on oxidative stress in elderly patients with diabetic peripheral neuropathy. Methods from August 2014 to June 2016, 120 elderly patients with diabetic peripheral neuropathy were divided into control group (n = 60) and observation group (n = 60). The control group was treated with 伪 -lipoic acid combined with insulin pump, while the observation group was treated with epalcitrate and 伪 -lipoic acid combined with insulin pump. The levels of serum superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and nerve conduction were compared between the two groups before and after treatment. Results compared with before treatment, the serum levels of SODH-Px, median nerve, common peroneal nerve motor and sensory conduction velocity in the two groups were significantly increased, and the amplitude of increase in the observation group was higher than that in the control group (P 0.05), and the total clinical effective rate in the observation group was significantly higher than that in the control group (P 0.05). Conclusion the treatment of epalrestat, 伪 -lipoic acid combined with insulin pump on diabetic peripheral neuropathy in elderly patients can significantly improve the clinical efficacy, improve oxidative stress response, improve nerve conduction velocity, promote the recovery of patients, and have a significant advantage in the treatment of senile diabetic peripheral neuropathy.
【作者单位】：冀中能源邢台矿业集团有限责任公司总医院;
【分类号】：R587.2

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