2型糖尿病合并亚临床甲状腺功能减退患者炎症因子水平测定及意义

发布时间：2018-05-18 00:02

本文选题：2型糖尿病 + 亚临床甲状腺功能减退症　；参考：《山西医科大学》2015年硕士论文

【摘要】：目的:探讨2型糖尿病合并亚临床甲状腺功能减退患者炎症因子TNF-α、IL-6、ICAM-1水平变化特点及其意义。方法:按照入组标准选取2014年10月至2015年3月山西医科大学第一附属医院内分泌科门诊及住院患者和健康体检者100例,分为四组:正常对照组10例(NC组),2型糖尿病组30例(T2DM组),亚临床甲减组30例(SCH组),2型糖尿病合并亚临床甲减组30例(T2DM+SCH组)。上述四组病例均排除原发性高血压、心脏疾病、肝脏疾病、慢性肾脏疾病、糖尿病合并的严重并发症等。记录研究对象的性别、年龄、诊断、现病史、既往史等,测定血清FT3、FT4、TSH、Hb A1c,酶联免疫吸附法(ELISA)法检测各组血清TNF-α、IL-6、ICAM-1水平,分析2型糖尿病合并亚临床甲状腺减退症患者血清TNF-α、IL-6、ICAM-1水平变化。结果:与NC组相比,其余三组TNF-α、IL-6及ICAM-1表达水平均增高,差异有统计学意义(P均0.05)。其中T2DM+SCH组TNF-α、IL-6表达水平最为显著(P0.05),而T2DM组与SCH组相比差异无统计学意义;SCH组ICAM-1表达水平最低(P0.05),且T2DM组与T2DM+SCH组相比差异无统计学意义。结论:1.2型糖尿病患者合并亚甲减后TNF-α、IL-6水平显著增高,其可能存在共同的慢性炎症起源。2.TNF-α、IL-6有可能成为评估2型糖尿病合并亚甲减患者大血管病变发病风险的早期诊断标志物,从而为临床诊疗提供指导。
[Abstract]:Objective: to investigate the changes and significance of inflammatory factor TNF- 伪 IL-6 in patients with type 2 diabetes mellitus complicated with subclinical hypothyroidism. Methods: from October 2014 to March 2015, 100 outpatients and inpatients in the Department of Endocrinology, the first affiliated Hospital of Shanxi Medical University, were selected according to the group criteria. The patients were divided into four groups: normal control group (n = 10) and subclinical hypothyroidism group (n = 30) with type 2 diabetes mellitus and subclinical hypothyroidism group (n = 30) respectively. There were 30 cases with type 2 diabetes mellitus complicated with subclinical hypothyroidism in the subclinical hypothyroidism group (n = 30). The four groups excluded essential hypertension, heart disease, liver disease, chronic kidney disease and severe complications of diabetes mellitus. The sex, age, diagnosis, present history, past history of the subjects were recorded. The serum levels of TNF- 伪 -TSHHbA1cand Elisa were measured by Elisa, and the levels of TNF- 伪 IL-6 and ICAM-1 were measured by Elisa. The changes of serum TNF- 伪 IL-6 and ICAM-1 levels in patients with type 2 diabetes mellitus complicated with subclinical hypothyroidism were analyzed. Results: compared with NC group, the expression levels of TNF- 伪 IL-6 and ICAM-1 in the other three groups were higher than those in NC group (P < 0.05). The expression of TNF- 伪 IL-6 in T2DM SCH group was the most significant, but there was no significant difference between T2DM group and SCH group. There was no significant difference in ICAM-1 expression level between Sch group and SCH group, and there was no significant difference between T2DM group and T2DM SCH group. Conclusion the level of TNF- 伪 and IL-6 in type 1.2 diabetic patients with hypothyroidism is significantly higher than that in patients with type 1. 2. TNF- 伪 IL-6 may be an early diagnostic marker for assessing the risk of macroangiopathy in patients with type 2 diabetes mellitus with hypothyroidism. So as to provide guidance for clinical diagnosis and treatment.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R587.1;R581.2

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