卵巢早衰与膳食营养相关研究

发布时间：2018-05-18 01:36

本文选题：膳食营养 + 卵巢早衰　；参考：《四川大学学报(医学版)》2017年04期

【摘要】：目的探讨膳食营养与卵巢早衰发病之间的关系,以便在膳食营养方面为卵巢早衰的预防提供依据。方法收集2015年11月至2017年1月于我院生殖内分泌门诊就诊的患者,以1∶3的病例对照设计,纳入病例组与对照组研究对象,分析两组间日实际摄入量、蛋白质日摄入量、碳水化合物日摄入量和膳食纤维日摄入量、维生素日摄入量、微量元素日摄入量的差异,进一步用多因素logistic回归,分析膳食营养与卵巢早衰发病之间的关系。结果本研究共纳入卵巢早衰组70例,对照组224例,卵巢早衰组18~40岁,平均31.41岁。对照组19~40岁,平均28.74岁。两组年龄、性别分布、身高、体质量、体质量指数(BMI)差异均无统计学意义,基线可比。日实际摄入量、蛋白质日摄入量、碳水化合物日摄入量和膳食纤维日摄入量在卵巢早衰组和对照组之间差异有统计学意义(P0.05)。多因素logistic回归分析显示,碳水化合物日摄入量过低者和膳食纤维日摄入量过低者是卵巢早衰的独立危险因素,其比值比(OR)值分别为11.652(95%CI:3.864~35.135)和7.851(95%CI:2.272~27.137)。结论碳水化合物及膳食纤维日摄入量的不足均可能增加卵巢早衰患病风险。
[Abstract]:Objective to explore the relationship between dietary nutrition and preterm ovarian failure (POF) in order to provide evidence for the prevention of premature ovarian failure (POF). Methods from November 2015 to January 2017, the patients in the reproductive endocrine clinic of our hospital were collected. The 1:3 case-control design was used to analyze the actual daily intake of protein and the daily intake of protein between the two groups. The differences of daily carbohydrate intake, dietary fiber intake, vitamin daily intake and trace element intake were analyzed by multivariate logistic regression to analyze the relationship between dietary nutrition and preterm ovarian failure. Results 70 cases of premature ovarian failure group and 224 cases of control group were included in this study. The average age of ovarian premature failure group was 31.41 years old (1840 years). The control group was 1940 years old (mean 28.74 years). There was no significant difference in age, sex distribution, height, body mass index (BMI) between the two groups, and the baseline was comparable. There were significant differences in daily actual intake, protein intake, carbohydrate intake and dietary fiber intake between premature ovarian failure group and control group (P 0.05). Multivariate logistic regression analysis showed that those with too low daily intake of carbohydrate and too low daily intake of dietary fiber were independent risk factors of premature ovarian failure. The ratio of CI: 3.864 to 35.135 was 11.65295 and 7.851-95CI: 2.272or 27.137respectively. Conclusion the deficiency of daily intake of carbohydrate and dietary fiber may increase the risk of premature ovarian failure.
【作者单位】：四川大学华西第二医院妇产科;出生缺陷与相关妇儿疾病教育部重点实验室(四川大学);
【基金】：国家自然科学基金(No.81270665) 四川省科技厅科技支撑计划项目(No.2012SZ0031)资助
【分类号】：R711.75

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