老年患者长期应用质子泵抑制剂对骨质疏松的影响研究

发布时间：2018-05-18 19:42

本文选题：质子泵抑制剂 + 骨质疏松　；参考：《重庆医学》2017年13期

【摘要】：目的探讨老年患者长期应用质子泵抑制剂(PPI)对骨质疏松的影响。方法选取2011年1月至2015年1月期间该院收治的消化性溃疡患者150例为观察组,选取同期健康体检老年人150例为对照组。记录两组人群年龄、身高、体质量、PPI用药时间,采用骨密度测定仪检测患者治疗前后骨密度变化情况,包括腰椎L1~4、桡骨密度及尺骨骨密度。观察并记录观察组老年患者治疗前、治疗半年、治疗1年及2年后骨密度变化情况。结果治疗后,观察组患者胃泌素明显增多,血钙水平及骨密度明显下降,差异有统计学意义(P0.05)。观察组老年患者腰椎、桡骨及尺骨骨密度明显低于对照组(P0.05)。随着PPI用药时间的延长,老年患者腰椎、桡骨及尺骨骨密度均呈下降趋势。结论老年患者长期应用PPI会造成骨密度降低。
[Abstract]:Objective to investigate the effect of proton pump inhibitor (PPI) on osteoporosis in elderly patients. Methods 150 patients with peptic ulcer treated in our hospital from January 2011 to January 2015 were selected as observation group and 150 healthy aged persons as control group. The age, height and body weight of the two groups were recorded. The changes of bone mineral density (BMD) before and after treatment were measured by BMD instrument, including lumbar L1C4, radius density and ulnar bone density. The changes of bone mineral density (BMD) were observed and recorded before treatment, half year, 1 year and 2 years after treatment in the observation group. Results after treatment, gastrin increased significantly, blood calcium level and bone mineral density decreased significantly in the observation group, and the difference was statistically significant (P 0.05). The bone mineral density of lumbar vertebrae, radius and ulna in the observation group was significantly lower than that in the control group (P 0.05). The bone mineral density of lumbar vertebrae, radius and ulna decreased with the prolongation of PPI. Conclusion long-term application of PPI in elderly patients will reduce bone mineral density (BMD).
【作者单位】：河北医科大学第三医院消化科;
【基金】：河北省卫生厅科研项目(20120335)
【分类号】：R580

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