超重或肥胖及高血糖对血脂异常的交互作用分析

发布时间：2018-05-19 20:37

本文选题：血脂异常 + 超重　；参考：《山东医药》2016年46期

【摘要】：目的探讨超重或肥胖及高血糖的交互作用对血脂异常患病的影响。方法采用分层随机抽样方法,抽取进行健康查体的体检者5 179例,依据血脂检测结果,将1 563例血脂异常者作为病例组,从其余3 616例无血脂异常者中选取与病例组年龄、性别相匹配的1 583例作为对照组。对两组体检者进行问卷调查,调查内容包括体检者的一般情况(如姓名、性别、年龄等)、疾病史、家族史及烟酒史等临床资料。测量两组身高及体质量,计算BMI。采集两组空腹静脉血5 m L,检测血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及空腹血糖(FPG)水平。使用非条件Logistic回归模型及相加模型对危险因素交互作用进行分析。结果病例组合并超重或肥胖、高血糖的发生率均高于正常组(P均0.01)。单因素Logistic回归分析显示,有超重或肥胖及高血糖者血脂异常的患病风险为体质量正常及无高血糖者的7.457倍,超重或肥胖与高血糖同时存在的交互作用指数(S)为1.13,超相对危险比(RERI)为0.72,归因比(AP)为9.60%。多因素Logistic回归分析显示,有超重或肥胖及高血糖者血脂异常的患病风险为体质量正常及无高血糖者的5.061倍,超重或肥胖与高血糖同时存在的S为1.07,RERI为0.28,AP为5.43%。结论高血糖与超重或肥胖对血脂异常的发生存在相加交互作用,两者同时存在时可增加血脂异常的患病风险。
[Abstract]:Objective to investigate the effects of overweight or obesity and hyperglycemia on the prevalence of dyslipidemia. Methods the stratified random sampling method was used to select 5 179 cases of health check-up. According to the results of blood lipid test, 1 563 cases of dyslipidemia were selected as the case group, and the age of the other 3 616 cases without dyslipidemia was selected as the age of the case group. Sex matched 1 583 cases as control group. A questionnaire survey was conducted among the two groups of physical examiners, which included general information (such as name, sex, age, disease history, family history, tobacco and alcohol history, etc.). The height and mass of the two groups were measured and BMIs were calculated. Fasting venous blood samples were collected from two groups, and the levels of serum total cholesterol (TCN), triglyceride (TGG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and fasting blood glucose (FPG) were measured. Non-conditional Logistic regression model and additive model were used to analyze the interaction of risk factors. Results the incidence of hyperglycemia in patients with overweight or obesity was higher than that in normal controls (P < 0.01). Univariate Logistic regression analysis showed that the risk of hyperlipidemia in overweight or obese and hyperglycemia patients was 7.457 times higher than that of normal body mass and no hyperglycemia. The interaction index between overweight or obesity and hyperglycemia was 1.13, the super-relative risk ratio (RERI) was 0.72, and the attribution ratio (APR) was 9.60. Multivariate Logistic regression analysis showed that the risk of dyslipidemia in patients with overweight or obesity and hyperglycemia was 5.061 times as high as those with normal body mass and no hyperglycemia. Conclusion there is an additive interaction between hyperglycemia and overweight or obesity, which can increase the risk of dyslipidemia.
【作者单位】：桂林医学院附属医院;南通大学附属海安医院;
【基金】：江苏省南通市卫生局青年科研基金项目(WQZ2015012)
【分类号】：R589.2;R587

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