静脉滴注前列地尔结合针灸治疗糖尿病足溃疡的临床观察

发布时间：2018-05-20 07:43

本文选题：前列地尔 + 针灸　；参考：《中国药房》2017年20期

【摘要】：目的:探讨静脉滴注前列地尔结合针灸治疗糖尿病足溃疡的临床疗效,及对患者炎症因子水平及创面微血管密度的影响。方法:选取2014年5月-2015年9月我院收治的糖尿病足溃疡患者72例,按随机数字表法分为观察组和对照组,各36例。对照组患者在给予胰岛素等基础治疗上应用前列地尔注射液10μg加入250 m L 0.9%氯化钠注射液中静脉滴注,qd;观察组患者在对照组基础上加针灸治疗(三阴交、足三里、丰隆、阳陵泉、阴陵泉等穴位),qd。两组疗程均为3周。比较两组患者的临床疗效、创面愈合时间、空腹血糖、尿微量白蛋白水平、炎症因子水平、创面微血管密度和不良反应发生情况。结果:观察组患者的总有效率(91.67%)显著高于对照组(72.22%),创面愈合时间显著短于对照组,差异均有统计学意义(P0.05)。治疗前,两组患者的空腹血糖、尿微量白蛋白和各炎症因子水平比较,差异均无统计学意义(P0.05);治疗后,两组患者的上述指标水平均显著低于治疗前,且观察组的尿微量白蛋白和各炎症因子水平显著低于对照组,差异均有统计学意义(P0.05)。治疗14、21 d后,观察组患者的创面微血管密度均显著高于同期对照组,差异均有统计学意义(P0.05)。两组患者均未见明显不良反应发生。结论:静脉滴注前列地尔结合针灸可通过减轻炎症反应、促进微血管生成,缩短糖尿病足溃疡患者的创面愈合时间,增强其疗效。
[Abstract]:Objective: to investigate the clinical effect of intravenous infusion of alprostadil combined with acupuncture on diabetic foot ulcer and its effect on inflammatory factor level and wound microvessel density. Methods: from May 2014 to September 2015, 72 patients with diabetic foot ulcer were randomly divided into observation group and control group, each with 36 cases. In the control group, 10 渭 g alprostadil injection was added into 250ml 0.9% sodium chloride injection by intravenous drip QD, while the patients in the observation group were treated with acupuncture and moxibustion (Sanyinjiao, Zusanli, Fenglong) on the basis of insulin. Yang Ling Spring, Yin Ling Spring and other acupoints such as QD. The course of treatment was 3 weeks in both groups. The clinical efficacy, wound healing time, fasting blood glucose, urinary albumin level, inflammatory factor level, wound microvessel density and adverse reaction were compared between the two groups. Results: the total effective rate (91.67) in the observation group was significantly higher than that in the control group (72.22), and the wound healing time in the observation group was significantly shorter than that in the control group (P 0.05). Before treatment, there was no significant difference in fasting blood glucose, urinary microalbuminuria and inflammatory factors between the two groups, and after treatment, the above indexes were significantly lower than those before treatment. The levels of urinary microalbumin and inflammatory factors in the observation group were significantly lower than those in the control group (P 0.05). After 14 days of treatment, the microvessel density of the patients in the observation group was significantly higher than that in the control group, and the difference was statistically significant (P 0.05). No significant adverse reactions occurred in both groups. Conclusion: intravenous infusion of alprostadil combined with acupuncture can reduce inflammation, promote microangiogenesis, shorten wound healing time and enhance the curative effect of diabetic foot ulcer patients.
【作者单位】：佛山市第五人民医院内三科;
【基金】：佛山市医学重点专科培育项目(No.Fspy3-2015027)
【分类号】：R587.2

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