红花黄色素针对老年糖尿病合并脑梗死患者血糖水平的影响

发布时间：2018-05-20 18:52

本文选题：红花黄色素 + 糖尿病合并脑梗死　；参考：《延边大学》2017年硕士论文

【摘要】：目的研究红花黄色素对老年糖尿病合并脑梗死病人,血液流变学、葡萄糖代谢以及对血浆C-肽水平的影响。方法选择单纯老年脑梗死患者60例,老年糖尿病合并脑梗死患者60例,健康年轻体检者60例,三组患者均抽取空腹及口服葡萄糖75g后静脉血,并检测血液流变学、血糖、C肽水平。老年糖尿病合并脑梗死组在常规治疗的基础上给予红花黄色素冻干粉针剂l00mg入生理盐水250ml静脉滴注,每天一次,以14天为1疗程。入院后第1天和第14天分别抽空腹静脉血和口服葡萄糖75g后静脉血,检测血液流变学、血糖、C肽水平。结果1、老年脑梗死病人全血粘稠度、红细胞还原指数、血浆粘度、红细胞凝集指数、红细胞比积明显高于年轻人(P0.05),空腹血糖和口服葡萄糖后2h、3h血糖较健康年轻人明显升高(P0.05),空腹C肽和健康年轻人无明显差异,而口服葡萄糖后1、2、3hC肽水平较健康年轻人明显升高(P0.05)。2、老年糖尿病合并脑梗死病人用红花黄色素治疗后,全血粘稠度、红细胞还原指数、红细胞凝集指数明显下降(P0.01),血浆粘度、红细胞比积显著下降(P0.05);空腹血糖、口服葡萄糖后1、2、3小时血糖较治疗前明显下降(P0.05);口服葡萄糖后1、2小时血清C肽水平明显升高(P0.05),口服葡萄糖后3小时C肽水平无明显变化(P0.05)。结论红花黄色素具有改善老年脑梗死合并糖尿病病人的血液流变学、葡萄糖代谢和C肽水平,对防治糖尿病及其并发症可能有一定的作用。
[Abstract]:Objective to study the effects of safflower yellow on hemorheology, glucose metabolism and plasma C-peptide levels in elderly diabetic patients with cerebral infarction. Methods 60 elderly patients with cerebral infarction, 60 elderly patients with diabetes complicated with cerebral infarction and 60 healthy young people were selected. The venous blood samples were collected from the three groups after 75 g of oral glucose and fasting, and the hemorheology was detected. Blood glucose C peptide level. The elderly diabetic patients with cerebral infarction were treated with safflower yellow lyophilized powder injection (l00mg) and normal saline 250ml once a day for 14 days as a course of treatment on the basis of routine treatment. On the 1st and 14th day after admission, the abdominal venous blood was emptied and the venous blood was taken after oral glucose 75 g. The hemorheology and the level of blood glucose C peptide were measured. Results 1. The whole blood viscosity, erythrocyte reduction index, plasma viscosity, erythrocyte agglutination index in the aged patients with cerebral infarction were determined. The specific hematocrit was significantly higher than that of the young people (P 0.05N), the fasting blood glucose (FBG) and the blood glucose at 2 h after oral glucose were significantly higher than that of the healthy young people (P 0.05), but there was no significant difference between the fasting C-peptide and the healthy young people. Compared with the healthy young people, the level of 3hC-peptide was significantly higher than that of healthy young people. The whole blood viscosity, erythrocyte reduction index, erythrocyte agglutination index, plasma viscosity and plasma viscosity of senile diabetic patients with cerebral infarction treated with safflower yellow pigment were significantly lower than those of healthy young people. The specific hematocrit decreased significantly (P 0.05), the fasting blood glucose, 1 ~ 2 h after oral glucose, and the level of serum C peptide increased significantly (P 0.05), and the level of C peptide did not change at 3 hours after oral glucose administration (P 0.05N), and the level of serum C peptide increased significantly (P 0.05) at 1 hour after oral administration of glucose (P < 0.05), and the level of serum C peptide increased significantly (P 0.05) at 1 hour after oral administration of glucose. Conclusion Safflower yellow can improve hemorheology, glucose metabolism and C-peptide level in elderly patients with cerebral infarction complicated with diabetes, and may play a role in the prevention and treatment of diabetes mellitus and its complications.
【学位授予单位】：延边大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.1;R743.3

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