中、低预混胰岛素类似物对2型糖尿病患者血糖波动的影响

发布时间：2018-05-21 17:27

本文选题：精蛋白锌重组赖脯胰岛素混和注射液R + 门冬胰岛素注射液　；参考：《东南大学学报(医学版)》2017年03期

【摘要】：目的:比较精蛋白锌重组赖脯胰岛素混和注射液50R(优泌乐50)和门冬胰岛素30注射液(诺和锐30)对2型糖尿病(T2DM)患者血糖波动的影响。方法:入组T2DM患者持续皮下输注胰岛素强化,血糖达标2 d后行优泌乐50或诺和锐30每日3次治疗,血糖再次达标后进入4 d交叉研究,全程96 h动态血糖监测(CGM)覆盖。结果:优泌乐50和诺和锐30对患者24 h平均血糖、平均血糖波动幅度(MAGE)、高血糖(10.0 mmol·L~(-1))和低血糖(3.9 mmol·L~(-1))曲线下面积(AUC)等差异均无统计学意义;但相同剂量的优泌乐50较诺和锐30能更好地改善男性患者的MAGE[(4.52±2.50)vs(5.53±1.90)mmol·L~(-1),P0.05];两组患者均无低血糖事件发生。结论:中、低预混胰岛素类似物对T2DM患者总人群血糖波动的影响相似,但中预混胰岛素能更好地控制男性T2DM患者血糖波动。
[Abstract]:Aim: to compare the effects of proline and proline mixture injection 50R (Umbelol 50) and insulin aspartic 30 injection (Nohe Rui 30) on blood glucose fluctuation in patients with type 2 diabetes mellitus (T2DM). Methods: the patients with T2DM received continuous subcutaneous infusion of insulin. After 2 days of blood glucose was up to the standard, the patients were treated with Ummex 50 or Noroch and Rui 30 three times a day. After the blood glucose was up to the standard again, the patients were subjected to 4 days cross study, and the whole course was covered with dynamic blood glucose monitoring (CGM) for 96 h. Results: there was no significant difference in 24 h mean blood glucose, mean blood glucose fluctuation amplitude (MAGEG), hyperglycemia (10. 0 mmol / L) and hypoglycemia (3. 9 mmol / L ~ (-1) between two groups. However, the same dose of UMP _ (50) could improve the MAGE of male patients better than that of Nor and Ri (P 0.05), and no hypoglycemic events occurred in both groups. Conclusion: medium and low premixed insulin analogues have similar effects on blood glucose fluctuation in total population of T2DM patients, but moderate premixed insulin can better control blood glucose fluctuation in male T2DM patients.
【作者单位】：南京医科大学;南京卫生学校江苏联合职业技术学院南京卫生分院护理系;南京医科大学附属南京医院(南京市第一医院)内分泌科;
【基金】：中国博士后基金资助项目(2015M581829) 江苏省科技厅科学基金资助项目(BL2014010) 南京市卫生局项目(YKK11110)
【分类号】：R587.1

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