老年男性代谢综合征患者血脂肪酸结合蛋白4与脂质代谢及体脂分布的相关性

发布时间：2018-05-23 19:03

本文选题：脂肪细胞型脂肪酸结合蛋白 + 代谢综合征　；参考：《中国老年学杂志》2017年05期

【摘要】：目的探讨老年男性代谢综合征(MS)患者血清中脂肪酸结合蛋白(FABP)4与脂质代谢及体脂分布的相关性。方法收集60~85岁老年男性122例,分为MS组72例、非MS组50例。按照MS组分数目分为5组:1组(0组分)、2组(1组分)、3组(2组分)、4组(3组分)、5组(≥4组分)。采用ELISA方法检测血清中FABP4水平,生物电阻抗法测定人体体脂百分比及腰臀脂肪比评估体脂分布情况及肥胖程度,分析FABP4与各脂质代谢指标及体脂分布的相关性。结果 MS组FABP4水平较非MS组显著升高〔(31.44±15.08)ng/ml vs(24.56±5.60)ng/ml,P0.01〕,随代谢组分增加,FABP4水平呈逐渐升高趋势(P0.01)。相关性分析表明血清FABP4与体重指数(BMI)、体脂百分比、腰臀脂肪比、甘油三酯(TG)、空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、糖化血红蛋白(Hb A1c)均呈正相关(r分别为0.798、0.493、0.720、0.333、0.553、0.267、0.467和0.470,均P0.01)。多元线性逐步回归分析显示BMI、FPG、腰臀脂肪比、体脂百分比、舒张压是影响血清FABP4的独立危险因素(b=0.596、0.240、0.325、-0.155、-0.148,均P0.05)。结论血清中FABP4高水平可增加老年男性MS风险,并参与脂质代谢紊乱及体脂的异常分布特别是腹型肥胖的形成。
[Abstract]:Objective to investigate the relationship between fatty acid binding protein (FABP4) and lipid metabolism and body fat distribution in elderly male patients with metabolic syndrome (MSM). Methods 122 male patients aged 60 ~ 85 years were divided into MS group (n = 72) and non-MS group (n = 50). According to the number of MS components, they were divided into 5 groups: group 1, group 0, group 2, group 1, group Serum FABP4 levels were measured by ELISA method, body fat percentage and waist-hip fat ratio were measured by bioelectrical impedance method. The distribution of body fat and the degree of obesity were evaluated. The correlation between FABP4 and lipid metabolism index and body fat distribution was analyzed. Results the level of FABP4 in MS group was significantly higher than that in non-MS group (31.44 卤5.60 卤5.60 ng / ml P 0.01). Correlation analysis showed that serum FABP4 had positive correlation with body mass index (BMI), body fat percentage, waist-to-hip fat ratio (WHR), triglyceride (TG), fasting blood glucose (FPG), fasting insulin (FINSN), insulin resistance index (HOMA-IRN), HbA1c). Multiple linear stepwise regression analysis showed that BMI-FPG, waist-to-hip fat ratio, percentage of body fat and diastolic blood pressure were independent risk factors affecting serum FABP4. Conclusion the high level of FABP4 in serum can increase the risk of MS in aged men, and participate in the disorder of lipid metabolism and abnormal distribution of body fat, especially the formation of abdominal obesity.
【作者单位】：南京医科大学附属常州第二人民医院老年病科;南京医科大学附属常州第二人民医院内分泌科;南京医科大学附属常州第二人民医院中心实验室;
【基金】：江苏省干部保健课题(BJ13028)
【分类号】：R589

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