H型高血压合并2型糖尿病患者血浆Hcy、Cyst-C水平与颈动脉内膜中层厚度的关系

发布时间：2018-05-23 22:58

  本文选题：H型高血压 + 糖尿病　； 参考：《广东医学》2017年06期

【摘要】：目的观察H型高血压合并2型糖尿病患者血浆同型半胱氨酸(Hcy)、胱抑素C(Cyst-C)水平与颈动脉内膜中层厚度(cIMT)的关系。方法收集符合入选标准的H型高血压合并2型糖尿病患者120例,应用彩色多普勒超声检查仪测定cIMT,根据颈动脉粥样硬化的程度分为3组,cIMT正常(cIMT0.9 mm)组、cIMT增厚(0.9 mm≤cIMT1.3 mm)组和颈动脉斑块(cIMT≥1.3 mm)组;按血压水平分为高血压1级(140~159/90~99mmHg)组、高血压2级(160~179/100~109 mmHg)组、高血压3级(≥180/110 mmHg)组,检测并比较3组间患者血糖、血脂、尿素氮、血肌酐、糖化血红蛋白(HbA_(1C))、血清Hcy、Cyst-C水平,分析血清Hcy、Cyst-C与颈动脉cIMT的关系。结果 (1)按cIMT分为3组,3组间血糖、血脂、尿素氮、血肌酐等比较差异无统计学意义(P0.05),血清Hcy、Cyst-C比较差异有统计学意义(P0.05),其水平随着cIMT增厚而增加;(2)按血压水平分为3组,高血压3级组血清Hcy、Cyst-C水平高于高血压1级、2级组,高血压2级组血清Hcy、Cyst-C水平高于高血压1级组(均P0.05),其水平随着血压水平升高而升高;(3)cIMT与Hcy、Cyst-C、HbA_(1C)、收缩压、舒张压呈正相关(r=0.256、0.358、0.280、0.580、0.306,均P0.05),进一步行二分类logistic回归分析显示Hcy、Cyst-C、HbA_(1C)、收缩压是cIMT增厚的独立危险因素(OR=55.257、1.545、3.121、1.154,均P0.05)。结论 H型高血压合并2型糖尿病患者血清Hcy、Cyst-C水平与颈动脉粥样硬化具有密切相关性,是cIMT增厚的独立危险因素。
[Abstract]:Objective to investigate the relationship between plasma homocysteine cystatin Cyst-C and carotid intima-media thickness (IMT) in patients with type H hypertension and type 2 diabetes. Methods 120 patients with H type hypertension and type 2 diabetes mellitus who met the inclusion criteria were collected. According to the degree of carotid atherosclerosis, cIMT was measured by color Doppler ultrasound, and was divided into 3 groups according to the degree of carotid atherosclerosis: the group with normal carotid atherosclerosis (cIMT1.3 0.9 mm) and the group with carotid plaques 鈮，

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