多发性硬化患者生活质量评估及其影响因素探讨

发布时间：2018-05-25 01:42

本文选题：多发性硬化 + 生活质量　；参考：《中风与神经疾病杂志》2017年07期

【摘要】：目的评估多发性硬化患者生活质量水平,并探讨其影响因素。方法收集2012年7月~2016年12月就诊于河南省人民医院复发缓解型多发性硬化患者(relapsing-remitting MS,RRMS)36例,继发进展性多发性硬化患者(secondary progressive MS,SPMS)21例作为研究对象。采用多发性硬化生活质量54项评分(Multiple Sclerosis Quality of Life-54 instrument,MSQo L-54)测试MS患者的生活质量;对所有研究对象进行认知功能、抑郁状态、疲劳、睡眠质量及日常生活能力评估。结果 (1)RRMS组及SPMS组患者躯体生活质量(RRMS组58.62±16.32;SPMS组28.77±15.99,P=0.000)、精神生活质量(RRMS组57.33±16.72;SPMS组36.27±23.50,P=0.000)均有下降,SPMS组下降更明显。多元逐步回归法分析,与MS生活质量相关因素中,Hamilton抑郁量表评分处于第一位(β=-0.516,P0.001),其次为反应躯体化残疾程度的EDSS评分(β=-0.372,P0.001),第三位为疲劳评分(β=-0.250,P=0.002)。结论 MS患者有不同程度的生活质量下降,SPMS患者更明显。EDSS评分、抑郁、疲劳影响患者生活质量,早期干预抑郁及疲劳,对于改善MS患者生活质量有益。
[Abstract]:Objective to evaluate the quality of life (QOL) of multiple sclerosis (MS) patients and explore its influencing factors. Methods from July 2012 to December 2016, 36 patients with relapsed and remission multiple sclerosis (RMS) from July 2012 to December 2016, and 21 patients with secondary multiple sclerosis (MS) secondary to progressive multiple sclerosis (MS) were studied. Multiple Sclerosis Quality of Life-54 instrument MSQo L-54 was used to measure the quality of life of MS patients, and all subjects were evaluated for cognitive function, depression, fatigue, sleep quality and ability of daily living. Results the quality of life (QOL) of RMS group and SPMS group were significantly lower than that of RMS group (58.62 卤16.32) and RMS group (28.77 卤15.9) and mental life quality of RMS group (57.33 卤16.72) and (36.27 卤23.50) P0.000). Multiple stepwise regression analysis showed that the score of Hamilton Depression scale was the first (尾 -0.516% P 0.001), followed by the EDSS scale (尾 -0.372n P 0.001), and the third was fatigue score (尾 -0.250 P 0.002P). Conclusion the quality of life of patients with MS is lower than that of patients with SPMS. Depression and fatigue affect the quality of life of patients. Early intervention of depression and fatigue is beneficial to improve the quality of life of patients with MS.
【作者单位】：河南省人民医院;首都医科大学宣武医院;
【分类号】：R744.51

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