四妙散结合塞来昔布治疗湿热蕴结型痛风性关节炎临床观察

发布时间：2018-05-25 17:07

本文选题：痛风性关节炎 + 四妙散　；参考：《中华中医药学刊》2017年02期

【摘要】：目的:探讨四妙散结合塞来昔布口服治疗急性痛风性关节炎的临床有效性和安全性。方法:对于120例痛风伴有高尿酸血症患者进行随机双盲对照研究,病例分为两组:治疗组和对照组,每组60例。治疗组患者给予四妙散结合塞来昔布口服,对照组患者给予双氯芬酸纳口服。疗程均为3周,治疗前后检测(UA)血尿酸,(ESR)血沉等指标,并记录临床症状的变化,进行分析比较。结果:治疗组和对照组的临床症状均有改善,两组在治疗后UA和ESR均有明显降低(P0.05),治疗组患者总有效率98.3%,对照组患者总有效率91.6%;两组比较差异有统计学意义,四妙散结合塞来昔布胶囊口服临床疗效优于单纯口服西药双氯芬酸钠。结论:医院自制中药制剂四妙散联合西药塞来昔布口服是治疗急性痛风性关节炎其中一种行之有效的方法,临床效果明显,值得在临床上推广使用。
[Abstract]:Objective: to investigate the clinical efficacy and safety of Simiao San combined with celecoxib in the treatment of acute gouty arthritis. Methods: 120 cases of gout with hyperuricemia were randomly divided into two groups: treatment group and control group, 60 cases in each group. The patients in the treatment group were given oral administration of Simiao San combined with celecoxib, and the patients in the control group were given diclofenac. The course of treatment was 3 weeks. Before and after treatment, the changes of clinical symptoms were recorded and analyzed. Results: the clinical symptoms of both the treatment group and the control group were improved, both UA and ESR were significantly decreased in the two groups after treatment, the total effective rate of the treatment group was 98.3%, the total effective rate of the control group was 91.6, the difference between the two groups was statistically significant. The clinical efficacy of Simiao Powder combined with Celecoxib capsule was better than that of diclofenac sodium alone. Conclusion: it is an effective method to treat acute gouty arthritis by oral administration of Simiao Powder and celecoxib, which is worth popularizing in clinic.
【作者单位】：大连市第二人民医院骨科;辽宁中医药大学附属医院;
【分类号】：R593.21

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