老年直肠癌伴2型糖尿病患者Dixon术后吻合口瘘发生与血清肝细胞生长因子、糖化血红蛋白水平的关系

发布时间：2018-05-26 20:32

  本文选题：直肠癌 + 型糖尿病　； 参考：《中国老年学杂志》2016年21期

【摘要】：目的探讨血清肝细胞生长因子(HGF)、糖化血红蛋白(Hb A1c)水平对老年直肠癌伴2型糖尿病(T2DM)患者行Dixon术后吻合口瘘发生情况的影响。方法接受Dixon术治疗的老年直肠癌伴T2DM患者34例作为观察组,31例行Dixon术的老年直肠癌不伴T2DM患者作为对照组。比较两组术中及术后情况。结果观察组血清HGF(t=6.673,P0.001)、Hb A1c(t=8.114,P0.001)的水平均高于对照组(P0.05);观察组术后住院时间(t=3.559,P=0.001)、术后吻合口瘘的发生率(χ~2=3.947,P=0.047)均大于对照组(P0.05);观察组术后2年累积生存率明显低于对照组(44.12%,15/34 vs 80.65%,25/31;Log-rankχ~2=6.050,P=0.014)。结论降低老年直肠癌伴T2DM患者的血清HGF、Hb A1c水平,可以有效减少老年患者Dixon术后吻合口瘘的发生,改善老年患者的术后恢复情况。
[Abstract]:Objective to investigate the effect of serum HGF, HbA1c on the occurrence of anastomotic fistula after Dixon in elderly patients with rectal cancer with type 2 diabetes mellitus (T2DM). Methods 34 cases of elderly rectal cancer with T2DM treated by Dixon were used as control group. 31 cases of elderly rectal cancer without T2DM were treated with Dixon operation as control group. The intraoperative and postoperative conditions were compared between the two groups. Results the levels of serum HGFA1cTX 8.114P0.001 in the observation group were higher than those in the control group (P 0.001), and the postoperative hospitalization time and the incidence of postoperative anastomotic fistula in the observation group were significantly higher than those in the control group (蠂 23.947P0.047), and the 2 year cumulative survival rate in the observation group was significantly lower than that in the control group (44.12 / 1534 vs 80.25 / 31P / P 0.014). Conclusion the decrease of serum HGF HbA1c level in elderly patients with T2DM can effectively reduce the occurrence of anastomotic fistula and improve the postoperative recovery of elderly patients with Dixon.
【作者单位】： 沈阳医学院附属中心医院普外四科;沈阳医学院附属中心医院放射线科;
【分类号】：R735.37;R587.1
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本文编号：1938798