基础胰岛素联合阿卡波糖对比预混胰岛素治疗2型糖尿病疗效和安全性的Meta分析

发布时间：2018-05-27 01:15

  本文选题：基础胰岛素 + 阿卡波糖　； 参考：《中国糖尿病杂志》2017年03期

【摘要】：目的系统评价基础胰岛素联合阿卡波糖对比预混胰岛素治疗T2DM的有效性和安全性,为临床治疗提供循证参考。方法计算机检索Medline、PubMed、Science Direct、Springer Link、相关期刊论文、万方和维普数据库从2000~2016年的文献,收集基础胰岛素联合阿卡波糖(试验组)对比预混胰岛素(对照组)治疗T2DM的随机对照试验(RCT),提取资料并进行质量评价后,采用RevMan 5.3和Stata 12.0统计软件进行Meta分析。结果共纳入21项RCTs,试验组818例,对照组809例。Meta分析结果显示,试验组FPG[SMD(95%CI)=-0.26(-0.42~-0.10),总体效应检验:Z=3.14,P=0.002]、2hPG[SMD(95%CI)=-0.27(-0.47~-0.07),总体效应检验:Z=2.66,P=0.008]、BMI[SMD(95%CI)=-0.83(-1.45~-0.20),总体效应检验:Z=2.6,P=0.009]及低血糖发生率[OR(95%CI)=0.33(0.22~0.48),总体效应模型:Z=5.66,P0.00001]低于对照组,而两组HbA_1c水平比较,差异无统计学意义[SMD(95%CI)=-0.20(-0.44~0.04),总体效应检验:Z=1.61,P=0.11]。结论基础胰岛素联合阿卡波糖治疗T2DM在降低患者FPG、餐后血糖、BMI及低血糖发生率方面均优于预混胰岛素。
[Abstract]:Objective to evaluate the efficacy and safety of basic insulin combined with acarbose in the treatment of T2DM. Methods A computer-based search of Medlinea PubMeden Science Direct Springer Link. Chinese Journal Full-text Database, Wanfang and Weipu databases from 2000 to 2016 was conducted. The basic insulin and acarbose (trial group) were collected and compared with premixed insulin (control group) in the randomized controlled trial of T2DM. After extracting the data and evaluating the quality, the Meta was analyzed by RevMan 5.3 and Stata 12.0. 缁撴灉鍏辩撼鍏，

本文编号：1939752