绝经后女性骨密度与雌激素水平、免疫细胞因子和骨代谢指标的相关性研究

发布时间：2018-05-27 19:57

本文选题：绝经后骨质疏松症 + 骨密度　；参考：《中国免疫学杂志》2017年08期

【摘要】：目的:分析绝经后女性骨密度变化及其与雌激素水平、免疫细胞因子和血清骨代谢指标的相关性。方法:将135名绝经后女性根据其腰椎骨密度(BMD)分为骨质疏松(OP)组(54例)、骨量减少组(43例)及正常组(38例)。测定三组研究对象血清雌二醇(E2)、骨源性碱性磷酸酶(BALP)、骨钙素(BGP)、抗酒石酸酸性磷酸酶-5b(TRAP-5b)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、转化生长因子-β(TGF-β1)水平,并分析其与BMD的相关性。结果:与正常组比,OP组和骨量减少组血清E2、TGF-β1、IL-10水平均显著降低(P0.05),血清BALP、BGP、TRAP-5b、IL-6及TNF-α水平均显著升高(P0.05);与骨量减少组比,OP组的血清E2水平更低,血清BALP、BGP、TRAP-5b、IL-6及TNF-α水平均更高,差异有统计学意义(P0.05)。E2、TGF-β1、IL-10与BMD呈正相关(P0.05);BALP、BGP、TRAP-5b、IL-6及TNF-α均与BMD呈负相关(P0.05)。低血清E2水平和高血清BALP、BGP、TRAP-5b、IL-6、TNF-α水平是绝经后女性BMD降低的独立影响因素(P0.05)。结论:绝经后女性E2水平降低,引起骨重建失衡及骨免疫炎症反应,该变化与BMD降低有关。
[Abstract]:Objective: to analyze the changes of bone mineral density (BMD) in postmenopausal women and its correlation with estrogen level, immune cytokines and serum bone metabolism. Methods: 135 postmenopausal women were divided into two groups according to their lumbar vertebrae bone mineral density (BMDs): 54 cases of Osteoporosis (OPO) group, 43 cases of osteopenia group (43 cases) and 38 cases of normal group. Serum levels of estradiol (E _ 2), bone alkaline phosphatase (BALP), osteocalcin (BGP), tartrate-resistant acid phosphatase -5b (TRAP-5b), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor- 伪 (TNF- 伪), transforming growth factor- 尾 (TGF- 尾 _ 1) were measured and their correlation with BMD was analyzed. Results: compared with the control group, the serum levels of E2TGF- 尾 1 and IL-10 in the op group and the osteopenia group were significantly lower than those in the control group, while the levels of serum BALPGPTRAP-5bC6 and TNF- 伪 were significantly higher in the op group than in the normal group, and the levels of serum E 2 and TNF- 伪 in the BALPGPP-5 BGPP-5bTNF- 伪 group were significantly higher than those in the control group, and the levels of serum E 2 in the op group were lower than those in the control group, and the levels of IL-6 and TNF- 伪 were higher in the BALPGPP-5bU group than in the control group. There was a positive correlation between IL-10 and BMD. The levels of IL-6 and TNF- 伪 were negatively correlated with BMD. The levels of low serum E2 and high serum BALPGP TRAP-5bTNF- 伪 were independent influencing factors for the decrease of BMD in postmenopausal women. Conclusion: the decrease of E _ 2 level in postmenopausal women leads to the imbalance of bone reconstruction and bone immune inflammation, which is related to the decrease of BMD.
【作者单位】：华中科技大学同济医学院附属梨园医院老年病科;
【基金】：湖北省自然科学基金资助项目(2016CFB542)
【分类号】：R580

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