痛风方联合西药治疗急性痛风性关节炎湿热夹瘀型临床研究

发布时间：2018-05-27 20:51

本文选题：急性痛风性关节炎 + 湿热夹瘀　；参考：《广州中医药大学》2016年硕士论文

【摘要】：目的：通过随机对照的方法,比较临床症状、实验室检查变化,观察并评价痛风方联合西药在治疗急性痛风性关节炎的临床疗效及安全性,探索中西药结合治疗对于控制急性期症状的优势。方法：选择符合纳入标准,中医证型属湿热夹瘀的急性痛风性关节炎患者60例,按随机数字表法随机分组,分为治疗组和对照组,各30例。治疗组予口服依托考昔片、秋水仙碱片、非布司他片加上痛风方,对照组予口服依托考昔片、秋水仙碱片、非布司他片；两组观察期均为7天。记录并分析治疗前后患者中医证候积分、临床症状的改变,血尿酸(UA)、血清C反应蛋白(CRP)、血沉(ESR)、肝肾功能(天门冬氨酸转氨酶AST、丙氨酸氨基转氨酶ALT、尿素UREA、肌酐CREA)测定的变化及不良反应。结果：治疗组与对照组中医疗效总有效率分别为100%和90%,治疗后两组的中医证候、关节疼痛均有缓解(P0.05),且治疗组的改善更显著；治疗后两组UA、CRP、ESR均下降(P0.05),且治疗组UA及CRP下降优于对照组；治疗后两组三大常规(血分析、尿组合、大便检查)及肝肾功能均未出现严重影响。结论：从临床观察及数据分析,得出两组均能改善中医证候、关节疼痛,且降低UA、CRP、ESR,治疗组在缓解中医证候和关节疼痛具有更明显优势,UA、CRP下降速度更快,故说明中西药结合治疗急性痛风性关节炎疗效优于单纯西药治疗。
[Abstract]:Objective: to observe and evaluate the clinical efficacy and safety of gout prescription combined with western medicine in the treatment of acute gouty arthritis. To explore the advantages of the combination of traditional Chinese and western medicine in the control of acute symptoms. Methods: sixty cases of acute gouty arthritis with dampness heat and stasis were selected and divided randomly into treatment group and control group with 30 cases each. The treatment group was treated with oral topoxime tablet, colchicine tablet, non-busulta tablet plus gout prescription, while the control group was given etacoxib tablet, colchicine tablet, and non-busulta tablet. The observation period of both groups was 7 days. To record and analyze the scores of TCM syndromes and the changes of clinical symptoms of patients before and after treatment. Changes and adverse reactions of serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), liver and kidney function (aspartate aminotransferase AST, alanine aminotransferase alt, urea UREAA, creatinine). Results: the total effective rate of TCM in treatment group and control group was 100% and 90%, respectively. After treatment, the TCM syndromes and joint pain in both groups were relieved (P 0.05), and the improvement of treatment group was more significant. The levels of UA and CRP in the treatment group were lower than those in the control group, and the three major routine (blood analysis, urine combination, stool examination) and liver and kidney function were not seriously affected after treatment. Conclusion: from clinical observation and data analysis, it is concluded that both groups can improve TCM syndromes, joint pain, and reduce UACRP ESR.The treatment group has more obvious advantages in relieving TCM syndromes and joint pain. Therefore, the combination of traditional Chinese medicine and western medicine is superior to western medicine in the treatment of acute gouty arthritis.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R589.7

【引证文献】