血清趋化因子水平与新诊断2型糖尿病患者认知功能的相关性研究

发布时间：2018-05-28 00:25

  本文选题：RANTES + 型糖尿病　； 参考：《医学研究生学报》2017年09期

【摘要】：目的糖尿病引起认知功能下降已成为研究热点。文中探讨新诊断2型糖尿病(T2DM)患者血清调节活化正常T细胞表达与分泌的趋化因子(RANTES)水平与认知功能障碍的关系,为临床新诊断T2DM伴认知功能障碍的防治提供新的治疗思路。方法回顾性分析2015年3月至2016年9月期间于唐山市工人医院就诊并首次确诊的123例T2DM患者一般资料及临床生化指标。采用酶联免疫吸附法(ELISA)测定血清RANTES水平,同时采用简易智能精神状态检查量表(MMSE)和重复性成套神经心理状态测验量表(RBANS)对所有患者的认知功能进行评定。最终依据MMSE评分将新诊断的T2DM患者分为T2DM非认知障碍组与T2DM认知障碍组。分析以上2组患者一般资料、血清RANTES水平及RBANS认知功能量表评分的差异。采用单因素相关及多元逐步回归分析RANTES与基线资料及认知评分的相关性。结果 T2DM认知障碍组血清RANTES为(2.62±0.37)mmol/L,与T2DM非认知障碍组[(2.29±0.36)mmol/L]比较明显升高(P0.05),T2DM认知障碍组即刻记忆、视觉广度、注意力、延迟记忆评分及RBANS量表总分分别为(70.90±14.71)、(92.90±15.50)、(87.80±16.45)、(88.02±14.28)和(82.92±11.07),与T2DM非认知障碍组[分别为(85.28±13.97)、(104.18±12.69)、(101.51±12.94)、(96.42±10.30)、(95.84±9.94)]比较均明显降低(P0.05);2组言语功能评分分别为(96.08±7.87)和(99.31±9.83),差异无统计学意(P=0.056);T2DM患者中RANTES与即刻记忆、视觉广度、言语功能、延迟记忆评分及RBANS量表总分呈负相关(r值分别为-3.48、-2.35、-2.01、-3.02和-4.17)。结论血清RANTES水平与认知障碍存在显著相关性。血清RANTES水平升高可作为监测新诊断T2DM患者伴有认知功能障碍的重要指标。
[Abstract]:Objective Diabetes mellitus (DM) induced cognitive impairment has become a hot research topic. To explore the relationship between the level of serum regulatory activated normal T cell expression and secreted chemokine (RANTES) and cognitive dysfunction in patients with newly diagnosed type 2 diabetes mellitus (T2DM), and to provide a new therapeutic approach for the prevention and treatment of newly diagnosed T2DM with cognitive dysfunction. Methods from March 2015 to September 2016, the general data and clinical biochemical indexes of 123 patients with T2DM who were first diagnosed in Tangshan Workers Hospital were analyzed retrospectively. The level of serum RANTES was measured by Elisa, and the cognitive function of all patients was evaluated by simple Mental State examination scale (MMSE) and repetitive Neuropsychological State Test scale (RBANS). According to the MMSE score, the newly diagnosed T2DM patients were divided into T2DM non-cognitive impairment group and T2DM cognitive impairment group. The general data, serum RANTES level and RBANS cognitive function scale scores of the two groups were analyzed. Single factor correlation and multiple stepwise regression analysis were used to analyze the correlation between RANTES and baseline data and cognitive score. Results the serum RANTES in T2DM cognitive impairment group was 2.62 卤0.37 mmol / L, which was significantly higher than that in T2DM non-cognitive disorder group [2.29 卤0.36)mmol/L]. 寤惰繜璁板繂璇勫垎鍙奟BANS閲忚〃鎬诲垎鍒嗗埆涓，

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