健康和糖尿病大鼠红细胞荧光光谱非线性程度差异

发布时间：2018-05-28 21:59

本文选题：糖尿病 + 红细胞　；参考：《光谱学与光谱分析》2016年10期

【摘要】：糖尿病是严重威胁人类健康的慢性疾病之一,对其进行早期诊断尤为重要。由于糖尿病病程的发展会对血液中红细胞的结构和功能产生影响,因此利用红细胞荧光光谱在特征峰位和峰高等方面的差异性,可以对糖尿病状态进行诊断。在选取光谱信号的差异性作为特征向量方面,可以采用荧光光谱信号的非线性程度作为特征向量。为更好地描述荧光光谱信号的非线性,采用延迟向量方差(DVV)法描述信号的非线性程度。采用迭代幅度匹配傅里叶变换(IAAFT)法产生原始数据的替代数据,通过比较原始数据与替代数据的延迟向量方差确定原始数据的非线性特征。以原始数据目标方差为横坐标,以其替代数据目标方差为纵坐标,画出延迟向量方差散布图。健康大鼠红细胞荧光光谱的延迟向量方差散布图与其对角线几乎重合,说明健康大鼠红细胞荧光光谱非线性程度较低;而糖尿病大鼠红细胞荧光光谱的延迟向量方差散布图偏离其对角线,说明糖尿病大鼠红细胞荧光光谱非线性程度较高,并且氨基酸对应的光谱段非线性程度更深。据此,提出健康和糖尿病荧光光谱之间的非线性差异程度可以作为糖尿病早期诊断的特征之一。
[Abstract]:Diabetes is one of the chronic diseases that threaten human health seriously, so it is very important to diagnose it early. Because the development of diabetes course will affect the structure and function of erythrocyte in blood, the difference of characteristic peak position and peak height of erythrocyte fluorescence spectrum can be used to diagnose the status of diabetes mellitus. In selecting the difference of spectral signal as eigenvector, the nonlinearity of fluorescence spectrum signal can be used as eigenvector. In order to better describe the nonlinearity of the fluorescence spectrum signal, the delay vector variance (DVV) method is used to describe the nonlinearity of the signal. The iterative amplitude matching Fourier transform (IAAFT) method is used to generate the substitute data of the original data, and the nonlinear characteristics of the original data are determined by comparing the variance of the delay vector between the original data and the substitute data. Based on the original data object variance as the transverse coordinate and its replacement data target variance as the vertical coordinate, the delay vector variance scatter diagram is drawn. The delay vector variance scatter diagram of red blood cell fluorescence spectrum of healthy rats almost coincided with its diagonal line, which indicated that the nonlinearity of erythrocyte fluorescence spectrum in healthy rats was lower. The delay vector variance scatter diagram of erythrocyte fluorescence spectrum of diabetic rats deviated from its diagonal line, which indicated that the nonlinear degree of erythrocyte fluorescence spectrum of diabetic rats was higher, and the nonlinear degree of amino acid corresponding spectrum was deeper. Therefore, the nonlinear difference between healthy and diabetic fluorescence spectra can be regarded as one of the characteristics of early diagnosis of diabetes mellitus.
【作者单位】：黑龙江中医药大学;哈尔滨工业大学电气工程及自动化学院;
【基金】：国家自然科学基金项目(81173186,61178066)资助
【分类号】：R587.1;O433.4

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