2型糖尿病患者血尿酸与非酒精性脂肪肝的相关性分析

发布时间：2018-05-29 04:01

本文选题：型糖尿病 + 尿酸　；参考：《南京医科大学学报(自然科学版)》2016年01期

【摘要】：目的:研究2型糖尿病(type 2 diabetic patients,T2DM)患者中血尿酸(serum uric acid,SUA)水平与非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)之间的关系。方法 :533例T2DM患者按SUA的四分位数将其分为4组(Q1~Q4),分析SUA水平与代谢指标及NAFLD之间的关系。结果:随着SUA水平的升高,T2DM患者的体重指数(body mass index,BMI)、收缩压、甘油三酯、空腹胰岛素及胰岛素抵抗指数(HOMA-IR)均显著升高,而高密度脂蛋白胆固醇则明显降低(组间趋势P均0.05);同时,患者的肝损标志物丙氨酸氨基转移酶和天门冬氨酸氨基转移酶亦随着SUA的升高而显著升高(组间趋势P0.001)。此外,从Q1组至Q4组,NAFLD的患病率逐渐递增(分别为41.2%、54.9%、59.3%和71.8%,组间趋势P0.001);多元Logistic回归分析进一步发现,在校正性别、年龄、BMI等因素后,Q4组的NAFLD患病风险较Q1组增加239%(OR=3.39,P=0.011)。结论:T2DM患者中SUA与NAFLD密切相关,是NAFLD的独立危险因素。
[Abstract]:Objective: to study the relationship between serum uric and NAF LDD in patients with type 2 diabetes mellitus (type 2 diabetic patientswith T2DM). Methods 533 patients with T2DM were divided into 4 groups according to the quartile of SUA. The relationship between SUA level and metabolic index and NAFLD were analyzed. Results: the body mass index (BMI), systolic blood pressure (SBP), triglyceride (TG), fasting insulin and insulin resistance index (HOMA-IRI) of T2DM patients increased significantly with the increase of SUA level, while the high density lipoprotein cholesterol (HDL-C) decreased significantly (P < 0.05). The liver damage markers alanine aminotransferase and aspartate aminotransferase also increased with the increase of SUA (P 0.001). In addition, the prevalence of NAFLD in Q1 group and Q4 group increased gradually (41.2% and 71.8%, respectively), and the trend between groups was P0.001.The multivariate Logistic regression analysis further found that the risk of NAFLD in Q4 group was 239OR3.39 P0.011g higher than that in Q1 group after adjusting for sex, age and other factors. Conclusion SUA is closely related to NAFLD and is an independent risk factor for NAFLD in patients with type 2 DM.
【作者单位】：上海市第一人民医院松江分院内分泌科;
【基金】：国家自然科学基金青年基金(81400785)
【分类号】：R587.1;R575.5

【相似文献】