伴高尿酸血症的急性脑梗死患者血尿酸水平与预后的关系

发布时间：2018-05-29 15:53

  本文选题：急性脑梗死 + 高尿酸血症　； 参考：《山东医药》2017年28期

【摘要】：目的探讨伴高尿酸血症的急性脑梗死患者血尿酸水平与预后的关系。方法选择伴高尿酸血症的急性脑梗死患者119例(尿酸升高组),其中60例接受降尿酸治疗、59例未接受降尿酸治疗,另选血尿酸水平正常的急性脑梗死患者88例(尿酸正常组)。两组入院后均予急性脑梗死常规治疗,尿酸升高组中60例在此基础上接受降尿酸治疗。分别于入院时,治疗1、2周及治疗3个月,检测接受或未接受降尿酸治疗者血尿酸水平。入院时及治疗1、2周,采用美国国立卫生研究卒中量表(NIHSS)评分评价脑梗死急性期神经功能损害程度。入院时、治疗3个月,采用改良PANKIN量表(MRS)评分评价脑梗死恢复期神经功能损害程度。以MRS评分≤2分为预后良好、MRS评分2分为预后不良,比较二者治疗3个月的预后情况。结果接受与未接受降尿酸治疗者入院时、治疗1周血尿酸水平比较P均0.05;接受降尿酸治疗者降尿酸治疗2周及治疗3个月血尿酸水平明显低于未接受降尿酸治疗者(P均0.05)。接受降尿酸治疗者随治疗时间延长,血尿酸水平逐渐降低(P0.05)。两组治疗前NIHSS、MRS评分比较P均0.05。尿酸升高组未接受降尿酸治疗者治疗1、2周NIHSS评分明显高于尿酸升高组接受降尿酸治疗者及尿酸正常组(P均0.05),治疗3个月MRS评分明显高于尿酸升高组接受降尿酸治疗者及尿酸正常组(P均0.05),而尿酸正常组与尿酸升高组接受降尿酸治疗者同期NIHSS、MRS评分比较P均0.05。治疗3个月,尿酸升高组未接受降尿酸治疗者预后良好率明显低于尿酸升高组接受降尿酸治疗者及尿酸正常组(P均0.05),而尿酸正常组与尿酸升高组接受降尿酸治疗者预后良好率比较差异无统计学意义(P0.05)。结论伴高尿酸血症的急性脑梗死患者预后较差,降尿酸治疗可改善患者预后。
[Abstract]:Objective to investigate the relationship between serum uric acid level and prognosis in patients with acute cerebral infarction with hyperuricemia. Methods 119 patients with acute cerebral infarction with hyperuricemia were selected. Among them, 60 patients were treated with hypouric acid and 59 patients were not treated with hypouric acid. 88 patients with acute cerebral infarction with normal serum uric acid level were selected. Both groups were treated with routine treatment of acute cerebral infarction after admission, 60 cases of patients with elevated uric acid were treated with hypouric acid on this basis. The serum uric acid levels were measured at admission, 1 ~ 2 weeks and 3 months respectively. At admission and 1 to 2 weeks of treatment, the NIH scale was used to evaluate the degree of neurological impairment in acute cerebral infarction. After 3 months of treatment, modified PANKIN scale was used to evaluate the degree of neurological impairment in convalescent stage of cerebral infarction. According to MRS score 鈮，

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