HIV相关型Kaposi肉瘤4例分析

发布时间：2018-06-02 10:31

本文选题：HIV + Kaposi肉瘤　；参考：《临床皮肤科杂志》2017年01期

【摘要】：目的:探讨HIV相关型Kaposi肉瘤的临床特点。方法:回顾性分析4例资料完整的HIV并发Kaposi肉瘤临床资料。结果:患者均为汉族人,皮损累及面部及口腔的3例,伴有双上肢皮损1例,肛周出现皮损1例。胸部CT均有微结节或弥漫性结节及毛玻璃影。皮损组织病理均诊断为Kaposi肉瘤,免疫组化结果:CD31(+),CD34(+),Ⅷ因子(+)3例,人疱疹病毒(HHV)-8(+)2例。CD4~+细胞数均低于1.2×10~8/L,平均0.495×10~8/L,HIV RNA均高于2.0×10~(10)拷贝/L,平均为5.77×10~(11)拷贝/L。结论:HIV相关型Kaposi肉瘤在汉族人中发病率极低,该病的发生有可能与CD4~+细胞数极低和病毒载量较高有关系。
[Abstract]:Objective: to investigate the clinical features of HIV associated type Kaposi sarcoma. Methods: the clinical data of 4 cases of HIV complicated with Kaposi sarcoma were analyzed retrospectively. Results: all the patients were Han nationality. The skin lesions involved the face and oral cavity in 3 cases, the skin lesions of both upper limbs in 1 case, and the perianal lesions in 1 case. All chest CT showed micronodules or diffuse nodules and fundus. The histopathological diagnosis of the lesions was Kaposi sarcoma. The immunohistochemical results were as follows: CD34 (3 cases), HHV-8 (2 cases), CD4~ (all less than 1.2 脳 10 ~ (8) / L, average 0.495 脳 10 ~ (8 / L) RNA were higher than 2.0 脳 10 ~ (10) copy / L, the average copy / L was 5.77 脳 10 ~ (-1) copy / L (P / L). Conclusion the incidence of Kaposi sarcoma in the Han nationality is very low, which may be related to the very low number of CD4 ~ cells and the high viral load.
【作者单位】：首都医科大学附属北京地坛医院皮肤性病科感染病科国家临床重点专科;首都医科大学附属北京地坛医院病理科;首都医科大学附属北京地坛医院口腔科;首都医科大学附属北京地坛医院感染一科感染病科国家临床重点专科;
【分类号】：R512.91;R730.26

【相似文献】