代谢综合征与肾透明细胞癌相关性研究

发布时间：2018-06-02 14:07

本文选题：代谢综合征 + 肾细胞癌　；参考：《中华肿瘤防治杂志》2017年06期

【摘要】：目的代谢综合征(metabolic syndrome,MS)是一组临床症候群,MS及其相关组分与癌症发生发展及病理特征具有密切关系。本研究旨在分析MS及其相关组分与肾透明细胞癌(clear cell cenal cell carcinoma,CCRCC)分期、分级及肿瘤大小的相关性。方法回顾性分析2013-01-01-2015-12-30于山西医科大学第一医院就诊且病理诊断为CCRCC的375例患者的临床资料,包括年龄、性别、身高、体质量、血压、空腹血糖、生化结果、病理分期分级和肿瘤大小等。计数资料采用χ2检验,计量资料以x-±s表示,组间比较采用t检验,多因素分析采用Logistic回归分析。结果 MS组56例患者,其中男性患者32例,女性患者24例;非MS组319例患者,其中男性患者206例,女性患者113例。男女患者比较,差异无统计学意义,P=0.287。MS组与非MS组相比,年龄、吸烟、饮酒等差异无统计学意义,P值分别为0.100、0.691和0.269;而BMI指数、收缩压、空腹血糖、TG、HDL-C等差异均有统计学意义,均P0.001。在病理特点方面,MS与非MS相比,CCRCC病理分期(P=0.018)、分级(P=0.026)及肿瘤大小(P=0.026),差异均有统计学意义。MS相关疾病与CCRCC分期分析,糖尿病(P0.001)、高血压(P=0.015)、血脂紊乱(P=0.006)与CCRCC的分期有关。结论 CCRCC合并MS者病理分期较高、分级较低、肿瘤更大,糖尿病、高血压和血脂紊乱都可增加CCRCC的病理分期。
[Abstract]:Objective Metabolic syndromes (MS) is a group of clinical syndromes MS and its related components are closely related to the occurrence and development of cancer and pathological features. The purpose of this study was to analyze the correlation between MS and its components in clear cell cenal cell carcinoma (CCRC) stage, grade and tumor size. Methods the clinical data of 375 patients with CCRCC, including age, sex, height, body weight, blood pressure, fasting blood glucose, biochemical results, were retrospectively analyzed. Pathological staging and tumor size. The counting data were analyzed by 蠂 2 test, the measurement data were expressed as x- 卤s, the comparison between groups was t test, and the Logistic regression analysis was used in multivariate analysis. Results there were 56 patients in MS group, including 32 males and 24 females, and 319 patients in non-MS group, including 206 males and 113 females. There was no significant difference in age, smoking and drinking between male and female patients (P < 0.01), but there were significant differences in BMI index, systolic blood pressure, fasting blood glucose and HDL-C between the two groups (P 0.001). The pathological features of MS were compared with those of non-MS. The pathological stages of CCRCC were P0.018, P0.026) and the size of tumor was 0.026. The difference was statistically significant. The differences of MS-related diseases and CCRCC staging were statistically significant. Diabetes mellitus P0.001, Hypertension 0.015D, dyslipidemia P0.006) were related to the staging of CCRCC. Conclusion the pathological stage of CCRCC complicated with MS is higher, lower grade, larger tumor, diabetes, hypertension and dyslipidemia can increase the pathological staging of CCRCC.
【作者单位】：山西医科大学第一医院泌尿外科;
【分类号】：R589;R737.11

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