比较分析卡托普利与美托洛尔治疗慢型克山病临床疗效及对患者心脏功能的不同影响对比

发布时间：2018-06-04 20:55

本文选题：卡托普利 + 美托洛尔　；参考：《中国地方病防治杂志》2016年02期

【摘要】：目的比较卡托普利与美托洛尔治疗慢型克山病的临床疗效及对患者心脏功能的影响。方法选择2014年1月~2015年12月在本院治疗的慢性克山病患者64例,根据随机数字表分为卡托普利组(n=32)和美托洛尔组(n=32)。两组患者均进行常规基础治疗,卡托普利组在基础治疗的基础上应用卡托普利,美托洛尔组在基础治疗措施的基础上使用美托洛尔。治疗后分别对两组患者死亡情况,临床症状改善情况以及心功能改善情况进行评估。结果卡托普利组病死率为3.13%,美托洛尔组无死亡。美托洛尔组治疗后心悸发生率显著高于卡托普利组(χ2=5.411,P0.05);卡托普利组治疗后气促和咳嗽发生率均显著高于美托洛尔组(P0.05)。治疗后两组患者心动过速、口唇发绀、以及浮肿等体征的发生率均较治疗前显著降低(P0.05)。治疗后两组患者LVESD和LVEDD均较治疗前显著降低(P0.05),LVEF均较治疗前显著升高(P0.05)。组间比较,治疗前后两组患者LVESD,LVEF和LVEDD比较差异均无统计学意义(P0.05)。组间比较,治疗前后两组患者心功能分级比较差异无统计学意义(P0.05)。结论卡托普利和美托洛尔均可显著改善慢型克山病患者心功能,缓解临床症状,但两种药物对部分临床症状的缓解作用存在差异。
[Abstract]:Objective to compare the effect of captopril and metoprolol on chronic Keshan disease. Methods Sixty-four patients with chronic Keshan disease treated in our hospital from January 2014 to December 2015 were randomly divided into captopril group (n = 32) and metoprolol group (n = 32). The patients in the captopril group were treated with captopril and the metoprolol group were treated with metoprolol on the basis of the basic treatment. After treatment, the death, clinical symptoms and cardiac function of the two groups were evaluated. Results the mortality of captopril group was 3.13%, and that of metoprolol group was not. The incidence of palpitation in the metoprolol group was significantly higher than that in the captopril group (蠂 ~ 2 = 5.411), and the incidence of shortness of breath and cough in the captopril group was significantly higher than that in the metoprolol group (P 0.05). After treatment, the incidence of tachycardia, cyanosis of lips and swelling in both groups were significantly lower than those before treatment. After treatment, LVESD and LVEDD in both groups were significantly lower than those before treatment. There was no significant difference in LVEF and LVEDD between the two groups before and after treatment (P 0.05). There was no significant difference in cardiac function between the two groups before and after treatment (P 0.05). Conclusion Captopril and metoprolol can significantly improve cardiac function and relieve clinical symptoms in patients with chronic Keshan disease.
【作者单位】：辽宁省鞍山市肿瘤医院药剂科;
【分类号】：R542.3

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