乌司他丁联合甲基强的松龙治疗急性有机氟中毒疗效观察

发布时间：2018-06-04 23:49

本文选题：乌司他丁 + 甲基强的松龙　；参考：《中国地方病防治杂志》2017年02期

【摘要】：目的探讨乌司他丁联合甲基强的松龙治疗急性吸入性有机氟中毒的临床疗效。方法抽取2011年7月至2015年12月在我院接受治疗的急性吸入性有机氟中毒患者51例,随机分组,对照组25例,观察组26例,对照组静脉滴注甲基强的松龙+生理盐水治疗,观察组静脉滴注乌司他丁+甲基强的松龙+生理盐水治疗,观察比较两组甲基强的松龙用量、疗程、肺部渗出吸收时间、病死率、不良反应发生情况及治疗前后患者中性粒细胞(PMN)、外周白细胞(WBC)、C反应蛋白(CRP)含量变化情况。结果观察组甲基强的松龙用量(1417.05±916.35)mg、疗程(6.35±1.64)d均小于对照组(5605.91±1641.58)mg、(11.33±6.32)d,差异具有统计学意义(P0.05);治疗3d后、7d后,观察组PMN、WBC、CRP均低于对照组,差异具有统计学意义(P0.05);观察组肺部渗出吸收时间低于对照组,差异具有统计学意义(P0.05);对照组经治疗无效死亡2例,观察组无死亡病例;不良反应发生率组间比较,差异无统计学意义(P0.05)。结论对急性吸入性有机氟中毒患者给予乌司他丁联合甲基强的松龙治疗,可有效改善患者中性粒细胞、外周白细胞及C反应蛋白水平,减少甲基强的松龙用量,缩短肺部渗出吸收及治疗时间,且安全性高,值得临床推广应用。
[Abstract]:Objective to investigate the clinical effect of ulinastatin combined with methylprednisolone in the treatment of acute inhaled organic fluorosis. Methods from July 2011 to December 2015, 51 patients with acute inhaled organic fluorosis were randomly divided into control group (n = 25), observation group (n = 26) and control group (n = 26). In the observation group, the dosage of methylprednisolone, the course of treatment, the time of pulmonary exudation and the mortality were observed and compared by intravenous infusion of ulinastatin methylprednisolone with normal saline. The incidence of adverse reactions and the changes of the contents of neutrophil PMN and WBC C reactive protein (CRP) in patients before and after treatment. Results the dosage of methylprednisolone in the observation group was 1417.05 卤916.35 mg / g, the course of treatment was 6.35 卤1.64 / d, which was lower than that in the control group (5605.91 卤1641.58) / mg / d (11.33 卤6.32 / d), and the levels of CRP in the observation group were significantly lower than those in the control group (P < 0.05). The difference was statistically significant (P 0.05), the time of pulmonary exudation absorption in the observation group was lower than that in the control group, the difference was statistically significant (P 0.05); in the control group, there were 2 cases of ineffective death after treatment, and there were no cases of death in the observation group; the incidence rate of adverse reactions was compared between the two groups. The difference was not statistically significant (P 0.05). Conclusion Ulinastatin combined with methylprednisolone can effectively improve the levels of neutrophils, peripheral white blood cells and C-reactive protein and reduce the dosage of methylprednisolone in patients with acute inhaled organic fluorosis. It can shorten the time of pulmonary exudation absorption and treatment, and has high safety, so it is worth popularizing in clinic.
【作者单位】：海南省人民医院;
【基金】：海南省自然科学基金项目(811379)
【分类号】：R595

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