老年男性2型糖尿病患者骨质疏松相关因素分析

发布时间：2018-06-05 11:10

本文选题：骨质疏松 + 型糖尿病　；参考：《江苏大学学报(医学版)》2016年02期

【摘要】：目的:探讨老年男性2型糖尿病患者发生骨质疏松的危险因素。方法:选取154例老年男性2型糖尿病住院患者,采用双能X线骨密度仪测定患者骨密度,根据测定结果将其分为骨密度正常组、骨量减少组和骨质疏松组,测定体质量指数(BMI)、糖化血红蛋白(Hb A1c)、空腹及餐后2 h血糖、空腹及餐后2 h C肽、血Ca2+、总胆固醇、血浆三酰甘油、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血尿酸、超敏C反应蛋白(hs-CRP)等指标。结果:1与骨密度正常组相比,骨量减少组和骨质疏松组患者的年龄、糖尿病病程均明显增高(P0.05),而BMI明显减低(P0.01)。2与骨密度正常组相比,骨量减少组和骨质疏松组患者的Hb A1c、hs-CRP均明显增高(P0.05),空腹及餐后2 h C肽明显降低(P0.05),而空腹及餐后2 h血糖、血Ca2+、总胆固醇、血浆三酰甘油、HDL-C、LDL-C、血尿酸等指标3组间差异无统计学意义(P0.05)。结论:老年男性2型糖尿病患者的骨密度与患者的年龄、病程和BMI有关,其中BMI是保护性因素,胰岛功能差、长期血糖控制不佳是导致骨质疏松的危险因素;hs-CRP在老年男性2型糖尿病患者骨质疏松的发生中有一定的作用。
[Abstract]:Objective: to investigate the risk factors of osteoporosis in elderly male patients with type 2 diabetes. Methods: 154 elderly male patients with type 2 diabetes mellitus were selected to measure their BMD by dual energy X-ray absorptiometry. According to the results, they were divided into normal BMD group, osteopenia group and osteoporosis group. Body mass index (BMI), glycosylated hemoglobin (HbA1cN), fasting and postprandial blood glucose, fasting and postprandial C-peptide, serum Ca 2, total cholesterol, plasma triacylglycerol, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), serum uric acid (uric acid) were measured. Hypersensitive C-reactive protein hs-CRP. Results compared with normal BMD group, the age and course of diabetes of patients with bone mass reduction and osteoporosis were significantly higher than those of normal BMD group, while BMI was significantly lower than that of normal BMD group. The levels of HbA1cnhs-CRP and C-peptide in fasting and 2 h postprandial group were significantly higher than those in control group and osteoporosis group, while fasting and 2 h postprandial blood glucose, serum Ca 2 and total cholesterol were significantly decreased. There was no significant difference in plasma triacylglycerol (HDL-C), serum uric acid and LDL-C between the three groups (P 0.05). Conclusion: BMD in elderly male patients with type 2 diabetes is related to age, course of disease and BMI. BMI is a protective factor and islet function is poor. Long-term poor blood glucose control is a risk factor for osteoporosis. Hs-CRP may play a role in the development of osteoporosis in elderly male patients with type 2 diabetes.
【作者单位】：江苏大学附属医院内分泌科;江苏大学附属医院消化科;江苏大学附属医院核医学科;
【分类号】：R587.1;R580

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