有氧、抗阻运动对糖尿病前期人群血清胰高血糖素样肽1、血糖水平的影响

发布时间：2018-06-05 21:40

本文选题：糖尿病 + 糖调节受损　；参考：《山东医药》2017年02期

【摘要】：目的观察有氧运动和抗阻运动对糖尿病前期人群胰高血糖素样肽1(GLP-1)及血糖水平的影响。方法105例糖尿病前期人群,随机分为A组34例、B组35例、C组36例。A组接受中等强度的有氧运动训练,B组接受抗阻运动训练,C组不进行运动干预,在干预前和干预第3、6、12、18个月,检测三组空腹血糖(FPG)、血清GLP-1、餐后2 h血糖(2 h PG),干预第18个月计算血清GLP-1变化率及血糖变化率。结果与干预前相比,A组干预第12、18个月时血清GLP-1水平升高,B组干预第6个月时降低、第18个月时升高,C组干预第6、12、18个月时降低(P均0.05);与C组相比,A、B组干预第12、18个月时血清GLP-1水平升高(P均0.05);与B组相比,A组干预第6、12个月时血清GLP-1水平升高(P均0.05)。与干预前相比,A组干预第3、6、12、18个月时FPG水平降低,B组干预第3、18个月时降低,C组干预第18个月时升高(P均0.05);与C组相比,A、B组干预第3、6、12、18个月时FPG水平降低(P均0.05)。与干预前相比,C组干预第3个月时2 h PG水平升高(P0.05);与C组相比,除B组干预第12个月外,A、B组干预各时点2 h PG水平降低(P均0.05)。105例研究对象干预18个月后GLP-1变化率与FPG变化率和2 h PG变化率均呈负相关(r分别为-0.537、-0.314,P均0.05)。结论有氧运动和抗阻运动均能减缓糖尿病前期人群血清GLP-1的下降趋势、降低血糖水平,有氧运动对GLP-1的改善效果优于抗阻运动。
[Abstract]:Objective to observe the effects of aerobic exercise and anti-resistance exercise on glucagon-like peptide 1 (GLP-1) and blood glucose level in prediabetic subjects. Methods 105 patients with prediabetes were randomly divided into group A (34 cases), group B (35 cases) and group C (36 cases). Group A received moderate intensity aerobic exercise training. Group B received resistance exercise training without exercise intervention. Fasting blood glucose (FBG), serum GLP-1 and 2 h postprandial blood glucose were measured in three groups. The change rate of serum GLP-1 and blood glucose were calculated at the 18th month after intervention. Results compared with before intervention, serum GLP-1 level in group A increased at the 12th month and decreased in group B at the 6th month. At the 18th month, the level of serum GLP-1 in group C was increased at the 12th month, and the level of serum GLP-1 in group A was significantly higher than that in group C at the 12th and 18th months, and the level of serum GLP-1 in group A was higher than that in group B at the 6th and 12th month after intervention (P < 0.05), and the level of serum GLP-1 in group A was significantly higher than that in group B (P < 0.05). The levels of FPG in group A were lower than those in group C at 18 months, and the levels of FPG in group B were lower than those in group C at 18 months, and the levels of FPG in group C were lower than those in group C at 18 months. Compared with the pre-intervention group, the level of PG in group C increased at 2 h after 3 months of intervention, and compared with group C, the level of PG in group C was higher than that in group C at 2 h after intervention. Except for the 12th month of intervention in group B, there was a negative correlation between the change rate of GLP-1 and the change rate of FPG and the change rate of PG at 2 h after intervention for 18 months (P < 0.05) in group A and group B (P < 0.05). Conclusion aerobic exercise and resistance exercise can both slow down the decreasing trend of serum GLP-1 and decrease the level of blood glucose in pre-diabetic population. Aerobic exercise can improve the effect of GLP-1 better than that of resistance exercise.
【作者单位】：广西医科大学第一附属医院;广西医科大学第九附属医院;
【基金】：广西医疗卫生适宜技术研究与开发课题项目(S201413_03) 广西研究生教育创新计划项目(YCSZ2015111)
【分类号】：R587.1

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