血清Fractalkine因子水平与肥胖和2型糖尿病的相关性研究

发布时间：2018-06-06 03:49

  本文选题：趋化因子Fractalkine + 糖尿病　； 参考：《中国糖尿病杂志》2017年11期

【摘要】：目的探讨血清Fractalkine(FKN)因子水平与肥胖和T2DM的相关性。方法根据BMI将88名健康体检者即糖耐量正常者(NGT)分为体重正常组(A组,n=44,BMI24kg/m~2)和超重肥胖组(B组,n=44,BMI≥24kg/m~2);将88例新诊断T2DM患者(T2DM组)分为体重正常组(C组,n=44,BMI24kg/m~2)和超重肥胖组(D组,n=44,BMI≥24kg/m~2)。ELISA测定FKN和肿瘤坏死因子α(TNF-α)水平。结果 T2DM患者FKN(0.625±0.090)ng/ml高于NGT者(0.395±0.110)ng/ml(P0.01),C组FKN(0.55±0.08)ng/ml高于A组(0.34±0.14)ng/ml和B组(0.45±0.08)ng/ml(P0.01)。T2DM患者FKN与FPG、HbAlc、WHR、BMI、C-RP、HOMA-IR、TNF-α呈正相关(r=0.578、0.592、0.616、0.596、0.909、0.872和0.827,P0.01),与HDL-C呈负相关(r=-0.216,P0.05)。多元回归分析显示,C-RP、BMI及TNF-α是FKN的独立相关因素(β=0.441、0.158和0.221,P0.05)。结论 T2DM患者FKN与炎症反应密切相关,可能参与了肥胖及T2DM的发生发展。
[Abstract]:Objective to investigate the relationship between serum Fractalkinesia FKN and obesity and T2DM. Methods according to BMI, 88 healthy persons with normal glucose tolerance were divided into two groups: normal body weight group (group A, n = 4) and overweight group (group B, n = 44 BMI 鈮，

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