血清Irisin水平与脂肪细胞型脂肪酸结合蛋白的相关性研究

发布时间：2018-06-08 05:55

本文选题：Irisin + 脂肪细胞型脂肪酸结合蛋白　；参考：《中国糖尿病杂志》2017年07期

【摘要】：目的探讨T2DM患者血清Irisin水平与脂肪细胞型脂肪酸结合蛋白(FABP4)的相关性。方法招募上海市奉贤区志愿者460名,根据75 g OGTT结果确定新诊断T2DM患者(T2DM组)56例,糖耐量正常者112名作为对照组(NGT)。测定糖脂代谢参数、Irisin及FABP4水平。结果 T2DM组WC、BMI、体脂百分比、SBP、DBP、ALT、TG、FPG、2 hPG、HbA_1c、HOMA-IR、SUA、eGFR较NGT组升高,HOMA-β低于NGT组(P0.05或P0.01)。Pearson相关性分析显示,Irisin与eGFR呈正相关;T2DM组血清Irisin与HbA_1c呈正相关(r=0.292,P=0.029),与FABP4呈负相关(r=-0.285,P=0.033)。校正年龄、BMI、体脂百分比、SBP、TC、eGFR,行多元线性回归分析结果显示,T2DM组HbA_1c和FABP4是Irisin的独立影响因素(R~2=0.350,P=0.025)。结论本研究表明,Irisin水平与糖脂代谢及肾功能密切相关。新诊断T2DM患者血清Irisin与FABP4呈负相关,提示Irisin可能有拮抗FABP4的作用。
[Abstract]:Objective to investigate the relationship between serum Irisin level and adipocyte fatty acid binding protein (FABP4) in patients with type 2 diabetes mellitus (T2DM). Methods A total of 460 volunteers from Fengxian District of Shanghai were recruited. According to the 75 g OGTT results, 56 patients with newly diagnosed T2DM and 112 patients with normal glucose tolerance were selected as control group. The levels of Irisin and FABP4 were measured. Results compared with NGT group, the percentage of body fat and body fat in T2DM group was significantly higher than that in NGT group (P 0.05 or P 0.01. Pearson). There was a positive correlation between Irisin and EGFR in T2DM group. There was a positive correlation between Irisin and HbA1c in T2DM group, and a positive correlation between Irisin and HbA1c in T2DM group, and a negative correlation between Irisin and HbA1c in T2DM group, and a negative correlation with FABP4. The results of multiple linear regression analysis showed that HbA1c and FABP4 in T2DM group were independent influencing factors of Irisin. Conclusion the level of Irisin is closely related to glucose and lipid metabolism and renal function. There was a negative correlation between serum Irisin and FABP4 in newly diagnosed T2DM patients, suggesting that Irisin might antagonize FABP4.
【作者单位】：南方医科大学附属奉贤医院内分泌代谢科;
【基金】：上海市科学技术委员会医学引导项目(134119b2500) 上海申康医院发展中心慢性病综合防治项目(SHDC12012302)
【分类号】：R587.1

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