老年骨质疏松患者骨代谢指标、骨密度与骨质疏松性骨折的相关性

发布时间：2018-06-09 01:33

本文选题：骨质疏松 + 骨折　；参考：《中国老年学杂志》2017年23期

【摘要】：目的研究老年骨质疏松(OP)患者骨代谢指标、骨密度(BMD)与OP性骨折的关系。方法 OP患者432例中发生OP性骨折194例为骨折组,非骨折238例为非骨折组,检测髋及腰椎BMD,抽血清检测25羟维生素D3[25-(OH)D3]、总Ⅰ型原胶原氨基端延长肽(PINP)、β胶原降解产物(β-CTX),采用Logistic回归分析OP性骨折的危险因素。结果骨折组BMD明显低于非骨折组,PINP、β-CTX均显著高于非骨折组,而25-(OH)D3显著低于非骨折组(P0.01)。年龄与体质指数(BMI)、BMD(股骨颈、股骨大转子、股骨转子间、总髋部、Ward三角区、腰椎等部位)及25-(OH)D3水平呈负相关(P0.01);与其他骨代谢指标无明显相关性。股骨颈、股骨大转子、股骨转子间、总髋部BMD与β-CTX呈负相关、与25-(OH)D3呈正相关(P0.05),与PINP无相关性;各部位BMD与女性、年龄呈负相关,与BMI呈正相关(P0.01)。β-CTX的升高、女性是骨折的危险因素,而25-(OH)D3是骨折的保护性因素。结论骨代谢指标和BMD及OP性骨折关系密切,β-CTX升高可用于骨折危险的预测,25-(OH)D3的升高可减少骨折的风险。
[Abstract]:Objective to study the relationship between bone metabolism, bone mineral density (BMD) and op fracture in elderly patients with Osteoporosis. Methods out of 432 patients with op, 194 had op fractures and 238 had no fractures. Hip and lumbar BMDs, 25 hydroxyvitamin D3 [25-OHHN D3], total procollagen PINPX, 尾 -CTX products (尾 -CTX) were detected. Logistic regression analysis was used to analyze the risk factors of osteovitamin D _ 3 (OHH _ 3), total procollagen amino-terminal lengthening peptide (PINPX) and 尾 -CTX (尾 -CTX). Results the BMD of fracture group was significantly lower than that of non-fracture group, 尾 -CTX was significantly higher than that of non-fracture group, while 25-OHHN D3 was significantly lower than that of non-fracture group (P 0.01). Age was negatively correlated with BMI BMID (femoral neck, greater trochanter of femur, intertrochanteric femur, total hip Ward triangle, lumbar vertebrae, etc.) and 25-OHHN D3 level was negatively correlated with BMD (P 0.01), but had no significant correlation with other bone metabolism indexes. BMD in femoral neck, trochanter, trochanter and total hip was negatively correlated with 尾 -CTX, positively correlated with 25-OHHN D3, but not correlated with PINP, and BMD was negatively correlated with age and BMI. Women are risk factors for fracture, and 25-OHN D 3 is a protective factor for fracture. Conclusion Bone metabolism is closely related to BMD and op fractures, and 尾 -CTX can be used to predict the risk of fracture. The increase of 25-OHH D3 may reduce the risk of fracture.
【作者单位】：福建医科大学附属第二医院骨科;
【基金】：福建省卫计委青年课题(No.2014-1-66)
【分类号】：R580;R683

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