糖尿病足细菌感染患者感染深度、C-反应蛋白、肿瘤坏死因子α、白介素-6及免疫蛋白水平与下肢血管病变的关系

发布时间：2018-06-09 06:03

本文选题：糖尿病足 + 细菌感染　；参考：《中华医院感染学杂志》2017年03期

【摘要】：目的探讨糖尿病足细菌感染患者感染深度、C-反应蛋白(CRP)、肿瘤坏死因子α(TNF-ɑ)、白介素-6(IL-6)及免疫蛋白水平与下肢血管病变(PAD)程度的关系,以期寻找二者间关系提供数据依据。方法选取医院2010年1月-2015年12月收治糖尿病足细菌感染患者435例,根据是否合并PAD分为合并组213例,未合并组222例,两组患者于入院后进行PAD程度及感染深度划分,于次日抽取肘静脉血标本进行炎性因子及免疫因子水平测定,观察两组患者不同感染深度、不同PAD程度间炎性因子及免疫因子水平。结果合并组感染越深发生PAD程度越高(P0.05),明显高于未合并组PAD同级别(P0.05),两组患者炎性因子水平越高发生PAD程度越高(P0.05),且合并组高于未合并组同炎性因子指标PAD同级别(P0.05),两组患者免疫因子水平越低发生PAD程度越高(P0.05),且合并组高于未合并组同免疫因子指标PAD同级别(P0.05)。结论糖尿病足细菌感染患者感染深度,CRP、TNF-ɑ、IL-6及免疫蛋白水平均与PAD具有相关性。
[Abstract]:Objective to investigate the relationship between the level of serum C- reactive protein (CRP), tumor necrosis factor 伪 (TNF- 伪), interleukin-6 (IL-6) and the degree of vascular lesions of lower extremity (PAD) in patients with bacterial infection of diabetic foot, so as to provide data basis for the relationship between them. Methods 435 patients with bacterial infection of diabetic foot were selected from January 2010 to December 2015 in our hospital. According to whether they were combined with pad, there were 213 cases in the combined group and 222 cases in the uncombined group. The degree of pad and the depth of infection were divided between the two groups after admission. The levels of inflammatory factors and immune factors in elbow vein blood samples were measured the next day, and the levels of inflammatory factors and immune factors between the two groups with different infection depth and pad degree were observed. Results the deeper the incidence of pad in the combined group was, the higher the pad degree was, which was significantly higher than that in the non-combined group (P 0.05). The higher the level of inflammatory factors in the two groups was, the higher the pad degree was, and the higher the pad level was in the combined group, and the higher the pad level was in the uncombined group. The lower the level of immune factor in the two groups was, the higher the pad degree was, and the higher the level of pad was in the combined group than that in the uncombined group, and the same level of pad was higher in the combined group than that in the uncombined group. Conclusion the levels of IL-6 and immunoglobulin in patients with bacterial infection of diabetic foot were correlated with pad.
【作者单位】：河南省人民医院南阳分院·南阳市中心医院内分泌科;
【基金】：河南省科技厅科技发展计划基金资助项目(14A320031)
【分类号】：R587.2

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