痛风患者血清铁蛋白和超敏C反应蛋白水平分析

发布时间：2018-06-09 21:47

  本文选题：痛风 + 高尿酸血症　； 参考：《卫生研究》2017年02期

【摘要】：目的分析男性血清铁蛋白水平和超敏C反应蛋白与痛风的关系及痛风患病风险。方法选择确诊为痛风病的男性患者600例作为痛风组,高尿酸血症者600例作为高尿酸血症组,随机抽取同期男性健康体检者600例为对照组。收集三组人群体检及相关指标的检测信息,如身高、体重、血清铁蛋白(SF)、超敏C反应蛋白(hs-CRP)、尿酸(UA)、空腹血糖(FPG)、甘油三酯(TG)、总胆固醇(TC)等。结果血清铁蛋白(SF)分析结果显示:痛风患者SF平均水平为135.27μg/L,明显高于高尿酸血症组114.45μg/L(P0.05)和对照组76.02μg/L(P0.05);而hs-CRP水平在痛风患者高达0.3 mg/dL,明显高于高尿酸血症组和对照组的0.13和0.09mg/d L(P均0.05)。在校正BMI、TG、TC、FPG和UA五项混杂因素后,高尿酸血症组和痛风组SF与hs-CRP水平呈正相关;而对照组SF与hs-CRP水平无关联。多因素Logistic回归分析,SF(≥69.01μg/L)是高尿酸血症发生的危险因素;在校正了BMI、TG、TC、FPG和UA五项混杂因素后,高水平的SF(≥155.78μg/L)是痛风发生的危险因素,OR为2.678(95%CI 1.484~4.833);且较高水平的hs-CRP(0.9 mg/dL)也是痛风发生的危险因素,OR为3.104(95%CI 1.727~5.580);而SF和hs-CRP并不是高尿酸血症发生的危险因素。结论痛风患者SF和hs-CRP明显升高,揭示SF、hs-CRP可能参与了痛风患者的发病过程。
[Abstract]:Objective to analyze the relationship between serum ferritin level, hypersensitive C reactive protein and gout and the risk of gout. Methods 600 male patients with gout were selected as gout group, 600 hyperuricemia patients as hyperuricemia group and 600 male healthy persons as control group. To collect the information of physical examination and related indexes of three groups, such as height, weight, serum ferritin, hypersensitive C-reactive protein hs-CRP, UAA, FBG, TGN, TCc, etc. Results the average level of SF in gout patients was 135.27 渭 g / L, which was significantly higher than that in hyperuricemia group (114.45 渭 g / L P 0.05) and control group (76.02 渭 g / L P 0.05), while the level of hs-CRP in gout patients was as high as 0.3 mg / dL, which was significantly higher than that in hyperuricemia group and control group (0.13 渭 g / L, P 0.05). After adjusting for the five confounding factors, the levels of SF and hs-CRP in hyperuricemia group and gout group were positively correlated, but there was no correlation between SF and hs-CRP level in control group. Multivariate logistic regression analysis showed that SF (鈮，

本文编号：2000940