蒙古族人群代谢综合征及其组分与糖尿病的关系

发布时间：2018-06-10 16:14

本文选题：代谢综合征 + 2型糖尿病　；参考：《苏州大学》2016年硕士论文

【摘要】：研究目的探讨蒙古族人群代谢综合征(MetS)及其各个组分与2型糖尿病发病的关系,以及探讨代谢综合征各组分的聚集程度与糖尿病发病的关系。研究对象与方法我们在2002-2003年间对内蒙古自治区通辽市奈曼旗固日班花苏木和科左后旗朝鲁吐苏木的32个自然村进行了基线调查,收集了人口统计学信息、生活方式等资料,并测量身高、体重、腰围和血压等;并且由经过严格培训的实验室人员进行血脂、血糖和胰岛素等的检测。2013-2014年间研究组进行随访调查,收集疾病史和用药史等资料,检测空腹血糖和餐后2小时血糖。资料收集完毕之后,核对整理所有的调查问卷,用Epidata3.1建立数据库,采用双人双遍录入方法进行数据的录入并进行核查和质量控制。采用logistic回归分析法分析代谢综合征及其组分的聚集程度与2型糖尿病发病的关系。应用SAS9.1统计软件进行统计分析,检验水准设为0.05。研究结果在2589名研究对象中,94人空腹血糖≥7.0mmol/L以及52人缺少重要的数据而被排除在外,完整的研究对象共2443人。在2443例研究对象中,249人死亡,305人失访,最终共1889人(男性722人,女性1167人)纳入了本次研究。1、基线时有大约24.83%的人群患有MetS,在MetS的五个组分中,患病率最高的为低HDL-C(54.90%),其次依次是血压偏高、中心性肥胖、FPG异常和高TG,患病率分别为46.32%、35.20%、19.69%和15.35%。与男性人群(19.25%)相比,女性人群中MetS的患病率(28.28%)相对较高。女性人群中心性肥胖和低HDL-C的发生率显著高于男性,而男性中高TG和血压偏高的患病率显著高于女性,男性和女性人群中空腹血糖异常情况无显著差异。2、在随访过程中,249人死亡,305人失访,随访率为77.32%。在整个随访的过程中,糖尿病发病者共有204例(男性83例,女性121人),累积发病率为10.67%,发病密度为98.05/万人年。其中男性糖尿病的累积发病率为11.50%,发病密度为105.67/万人年;女性糖尿病的累积发病率为10.37%,发病密度为95.20/万人年。3、与未发生糖尿病的人群相比,发生糖尿病者基线时中心性肥胖、血压偏高、高TG、低HDL-C、FPG异常和MetS的比例均更高(P0.05)。性别分层后发现,与未发生糖尿病人群相比,糖尿病组的中心性肥胖、血压偏高、高TG、低HDL-C、FPG异常和MetS的比例均较高(P0.05)。4、多因素logistic回归分析结果表明,MetS者发生糖尿病的风险性显著高于正常者,其OR值为3.53(2.56-4.87);糖尿病发病的风险性随着MetS的组分聚集程度的增加而增加(P0.001)。对于MetS的各个组分,我们发现中心性肥胖、血压偏高、高TG、低HDL-C以及FPG异常都与糖尿病发生的危险性增加有关,其OR值分别为2.05(1.45-2.91)、1.56(1.11-2.18)、1.58(1.04-2.39)、1.87(1.24-2.82)和2.33(1.66-3.28)。5、与无MetS者相比,男性和女性人群中MetS者发生糖尿病的危险性都显著增加,其OR值分别为2.96(1.77-4.97)和3.65(2.38-5.59),并且糖尿病的发病风险性随着MetS组分的聚集度的增加而增加。而对于Met S的各个组分,男性人群中仅低HDL-C和FPG异常组与糖尿病的发生显著相关,OR值分别为2.50(1.42-4.42)和1.81(1.03-3.21);而对于女性人群,MetS的各组分中中心性肥胖、血压偏高、高TG以及FPG异常组与糖尿病的发生显著相关,OR值分别为2.48(1.56-3.95)、1.58(1.02-2.45)、2.16(1.22-3.84)和2.74(1.76-4.26)。研究结论1、内蒙古族居民有着较高的2型糖尿病发病率,糖尿病已严重威胁当地居民的健康。2、相对于正常者,代谢综合征患者发生2型糖尿病的危险性显著增加。3、糖尿病发病风险随着MetS组分数量的增加而增加。在总人群中,MetS的五个组分都是糖尿病的重要危险因素,在男性人群中,低HDL-C以及FPG异常组分是糖尿病发生的重要危险因素,而对于女性人群来说,中心性肥胖、血压偏高、高TG以及FPG异常则与糖尿病的发生有关。
[Abstract]:Objective to investigate the relationship between the metabolic syndrome of Mongolian population (MetS) and its components and the onset of type 2 diabetes, and to explore the relationship between the degree of aggregation of the components of the metabolic syndrome and the onset of diabetes. The object and methods of the study were in 2002-2003 years, in Naiman Banner, Tongliao, the Inner Mongolia Autonomous Region. A baseline survey was conducted in 32 natural villages of rupui Su, which collected data on demographic information, life style, and measured height, weight, waistline and blood pressure, and was followed up by a highly trained laboratory staff for blood lipids, blood glucose and insulin for.2013-2014 years to collect the history of disease. The data of fasting blood glucose and 2 hours postprandial blood glucose were tested and the data were collected. After the data were collected, all the questionnaires were checked, the database was established with Epidata3.1, the data was recorded and checked and the quality control was carried out by double and double entry methods. The logistic regression analysis was used to analyze the metabolic syndrome and its components. The relationship between the degree of aggregation and the incidence of type 2 diabetes. The SAS9.1 statistical software was used for statistical analysis. The test level was set to 2589 subjects, 94 people had fasting blood glucose more than 7.0mmol/L, and 52 people were missing important data. The total number of subjects was 2443. Among the 2443 subjects, 249 people died, A total of 1889 people (722 men and 1167 women) were included in the study of.1. At baseline, about 24.83% of the population had MetS. In the five components of MetS, the highest prevalence rate was low HDL-C (54.90%), followed by high blood pressure, central obesity, FPG abnormalities and high TG, and the prevalence rates were 46.32%, 35.20%, 19.69% and 15.35%., respectively. Compared with the male population (19.25%), the prevalence rate of MetS (28.28%) was relatively high in the female population. The incidence of central obesity and low HDL-C in women was significantly higher than that in men. The prevalence rate of high TG and high blood pressure in male was significantly higher than that in women. There was no significant difference between male and female people with abnormality in abnormality of hollow abdominal blood glucose (.2), during the follow-up period, 249 people died and 305 were lost, and the follow-up rate was 77.32%. during the whole follow-up period. There were 204 cases of diabetes mellitus (83 males and 121 females). The cumulative incidence was 10.67% and the density was 98.05/ million years. The cumulative incidence of diabetes in men was 11.50%, the incidence of the disease was 105.67/ million years, and the cumulative incidence of diabetes in women. The rate was 10.37%, the incidence of the disease was 95.20/ ten thousand people.3. Compared with the non diabetic population, the diabetic patients had central obesity, high blood pressure, high TG, low HDL-C, FPG abnormality and MetS ratio higher (P0.05). TG, low HDL-C, FPG abnormality and MetS ratio were higher (P0.05).4. The multivariate logistic regression analysis showed that the risk of diabetes in MetS was significantly higher than that of normal persons, and the OR value was 3.53 (2.56-4.87); the risk of diabetes was increased with the increase of MetS component aggregation (P0.001). It was found that central obesity, high blood pressure, high TG, low HDL-C, and FPG abnormalities were associated with increased risk of diabetes, and their OR values were 2.05 (1.45-2.91), 1.56 (1.11-2.18), 1.58 (1.04-2.39), 1.87 (1.24-2.82) and 2.33 (1.66-3.28).5. The risk of diabetes in males and females was significantly higher than those without MetS. Increased OR values were 2.96 (1.77-4.97) and 3.65 (2.38-5.59), and the risk of diabetes increased with the increase in the aggregation of MetS components. For each component of Met S, only low HDL-C and FPG abnormal groups in the male population were significantly related to the occurrence of diabetes, and OR values were 2.50 (1.42-4.42) and 1.81 (1.03-3.21), respectively. In the female population, central obesity, high blood pressure, high TG and FPG abnormal groups were significantly associated with diabetes, OR values were 2.48 (1.56-3.95), 1.58 (1.02-2.45), 2.16 (1.22-3.84) and 2.74 (1.76-4.26). Conclusions 1, Inner Mongolia residents have a higher incidence of type 2 diabetes, and diabetes has been seriously threatened. The risk of type 2 diabetes in the patients with metabolic syndrome was significantly increased by.3 compared with those of the normal people. The risk of diabetes was increased with the increase of the MetS group. In the total population, the five components of MetS were all important risk factors for diabetes, and in the male population, the low HDL-C and the abnormal FPG components were diabetes. The important risk factors for the disease are the central obesity, high blood pressure, high TG and FPG abnormalities.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R587.1;R589

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