丙氨酰谷氨酰胺对重症有机磷中毒患者神经和胃肠功能的影响

发布时间：2018-06-10 17:57

本文选题：重症有机磷中毒 + 丙氨酰谷氨酰胺　；参考：《中国药房》2016年29期

【摘要】：目的:探讨丙氨酰谷氨酰胺对重症有机磷中毒患者神经和胃肠功能的影响。方法:选择重症有机磷中毒患者46例,按入院先后顺序随机分为对照组和观察组,各23例。对照组患者给予解毒剂阿托品、复能剂氯解磷定、血液灌流以及其他对症处理。观察组患者在对照组基础上给予丙氨酰谷氨酰胺注射液0.5 g/kg,ivgtt,qd。两组患者均连续治疗3 d。比较两组患者中毒症状消失时间、全血胆碱酯酶恢复时间、住院时间及神经和胃肠功能指标。结果:观察组患者中毒症状消失时间、全血胆碱酯酶恢复时间、住院总时间均明显短于对照组,差异有统计学意义(P0.05)。治疗后,观察组患者血清二胺氧化酶、乳果糖/甘露醇明显低于对照组,血清瓜氨酸含量高于对照组,差异有统计学意义(P0.05)。治疗后,观察组腓总神经的运动神经传导速度、感觉神经传导速度明显高于对照组,F波潜伏期明显短于对照组,差异均有统计学意义(P0.05)。结论:丙氨酰谷氨酰胺能促进重症有机磷中毒患者病情缓解,改善肠黏膜功能和神经功能。
[Abstract]:Objective: to investigate the effects of alanyl glutamine on nervous and gastrointestinal function in patients with severe organophosphorus poisoning. Methods: 46 patients with severe organophosphorus poisoning were randomly divided into control group (n = 23) and observation group (n = 23). The patients in the control group were treated with antidote atropine, reactivator chlorophosphoridine, hemoperfusion and other symptomatic treatments. The patients in the observation group were given alanine glutamine injection 0.5 g / kg / kg iv GTT QD on the basis of the control group. The patients in both groups were treated continuously for 3 days. The time of disappearance of poisoning symptoms, the time of whole blood cholinesterase recovery, the time of hospitalization and the indexes of nerve and gastrointestinal function were compared between the two groups. Results: the time of disappearance of toxic symptoms, the recovery time of whole blood cholinesterase and the total hospitalization time of the patients in the observation group were significantly shorter than those in the control group, and the difference was statistically significant (P 0.05). After treatment, the levels of serum diamine oxidase, lactulose / mannitol in the observation group were significantly lower than those in the control group, and the level of serum citrulline was higher than that in the control group (P 0.05). After treatment, the motor nerve conduction velocity and sensory nerve conduction velocity of the common peroneal nerve in the observation group were significantly shorter than those in the control group (P 0.05). Conclusion: alanyl glutamine can promote the remission of patients with severe organophosphorus poisoning and improve intestinal mucosal function and nerve function.
【作者单位】：邢台市人民医院门诊部;
【基金】：邢台市科技计划项目(No.2011ZC028)
【分类号】：R595.4

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