IL-2、IL-17和TNF-α水平与合并原发性甲状腺功能减退症的不孕症患者相关性研究

发布时间：2018-06-11 18:12

本文选题：白细胞介素 + 肿瘤坏死因子　；参考：《安徽医科大学学报》2017年12期

【摘要】：观察合并原发性甲状腺功能减退症的不孕症患者血清白细胞介素(IL)-8、IL-17和肿瘤坏死因子(TNF)-α的水平,探讨其与发病的相关性。选取合并甲减的不孕症患者32例,甲状腺功能正常的不孕症患者53例,30例体检正常育龄妇女作为对照。检测所有被检者血清IL-2、IL-17和TNF-α的水平。IL-2水平在甲功正常不孕组与对照组相似,但明显高于甲减不孕组(P0.05);IL-17水平在对照组、甲功正常不孕组及甲减不孕组依次升高(P0.01);TNF-α水平在甲减不孕组与甲功正常不孕组相似,但均高于对照组(P0.01)。合并甲状腺功能减退症的不孕症患者血清IL-2水平降低,IL-17和TNF-α水平升高。IL-2可能仅参与了甲状腺功能减退的起病,而IL-17在不孕症和甲状腺功能减退起病中均起到重要作用。
[Abstract]:The levels of serum interleukin (IL) -8, IL-17 and tumor necrosis factor (TNF) - alpha in patients with primary hypothyroidism were observed and their correlation with the disease was investigated. 32 cases of infertility with hypothyroidism, 53 cases of normal thyroid dysfunction and 30 normal women of childbearing age as control were examined. The level of level.IL-2 of serum IL-2, IL-17 and TNF- a in all subjects was similar to that of control group, but significantly higher than that of hypothyroidism group (P0.05), and IL-17 level in control group, normal infertility group and hypothyroidism group (P0.01) in control group (P0.01), TNF- alpha water was similar to the normal infertility group in the hypothyroidism group and the thyroidism group, but the level of TNF- alpha was high. In the control group (P0.01), the level of serum IL-2 in the patients with hypothyroidism with hypothyroidism decreased, and the elevated levels of IL-17 and TNF- alpha may only participate in the onset of hypothyroidism, and IL-17 plays an important role in the onset of infertility and hypothyroidism.
【作者单位】：安徽医科大学第一附属医院内分泌科;
【基金】：安徽省高校省级自然科学研究项目(编号:KJ2013Z112) 安徽省自然科学基金(编号:1608085MH207)
【分类号】：R581.2;R711.6

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