利拉鲁肽对2型糖尿病患者炎症反应及血清脂联素的影响

发布时间：2018-06-12 10:24

本文选题：利拉鲁肽 + 型糖尿病　；参考：《中国老年学杂志》2016年07期

【摘要】：目的探讨利拉鲁肽对2型糖尿病(T2DM)患者炎症反应及血清脂联素(APN)的影响。方法选择该院内分泌科2013年6月至2014年6月收治的T2DM患者42例为T2DM组,选择同期健康检查者42例作为对照组,T2DM组采用利拉鲁肽皮下注射治疗,连续使用12 w。观察两组治疗前及T2DM组治疗前后体质指数(BMI)、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、总甘油三酯(TG)、空腹血糖(FPG)、口服糖耐量测试(OGTT)2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)、白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α、超敏C反应蛋白(hs-CRP)和血清APN的改变。结果治疗前,T2DM组BMI、FPG、OGTT 2 h PG、Hb A1c、IL-6、TNF-α、hs-CRP水平均显著高于对照组,血清APN水平显著低于对照组(均P0.05)。T2DM患者治疗后,FPG、OGTT 2 h PG、Hb A1c、IL-6、TNF-α、hs-CRP水平均显著低于治疗前,血清APN水平显著高于治疗前(均P0.05)。结论利拉鲁肽治疗T2DM患者,不仅能有效控制血糖,而且能显著降低炎症水平、血清APN水平,值得临床推广使用。
[Abstract]:Objective to investigate the effect of rialuru peptide on inflammatory response and serum adiponectin (APN) in patients with type 2 diabetes mellitus (T2DM). Methods from June 2013 to June 2014, 42 patients with T2DM were selected as T2DM group and 42 patients with T2DM as control group. The body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), total triglyceride (TGN), fasting blood glucose (FBG), OGTT (2 h) blood glucose 2 h (PGG), glycosylated hemoglobin (HbA1cU), interleukin (IL) were observed before treatment and before and after treatment in the T2DM group. The changes of IL-6, TNF- 伪, Hs-CRP and serum APN were observed. Results before treatment, the levels of PGHb HbA1cTNF- 伪 hs-CRP and serum APN were significantly lower in BMIG OGTT 2 h group than those in control group (all P0.05U. T2DM patients were treated with OGTT 2 h PGHb A1cTNF- 伪 -hs-CRP), and the serum APN level was significantly higher than that before treatment (P 0.05). Conclusion Lilaru peptide can not only effectively control blood glucose, but also significantly reduce the level of inflammation. The serum APN level is worth popularizing.
【作者单位】：海口市人民医院内分泌科;
【基金】：2011年海南省自然科学基金项目(No.811151)
【分类号】：R587.1

【相似文献】