抗神经节苷脂抗体在神经精神狼疮的临床意义

发布时间：2018-06-13 04:38

本文选题：抗神经节苷脂抗体 + 神经精神性狼疮　；参考：《青岛大学》2015年硕士论文

【摘要】：目的研究抗神经节苷脂抗体在神经精神狼疮(NPSLE)患者中的临床诊断意义,为患者的诊断寻求有效的依据。方法将2010年1月-2010年6月我院收治的23例系统性红斑狼疮患者(SLE)作为本次研究的观察组,包括神经精神性狼疮(NPSLE)12例与非神经精神性狼疮(非-NPSLE)11例;另外选取10例同期行健康体检的正常成年人作为本次研究的对照组,对本次研究对象的血清与脑脊液进行分析比较。结果对照组人员中的血清中抗GM1 Ig G、Ig M水平在系统性红斑狼疮患者与正常人之间差异有统计学意义(P0.01);血清中抗GM1 Ig G、Ig M阳性率,在NPSLE均为25.0%,在非-NPSLE均为18.2%,二者在抗体阳性率和水平上差异无统计学意义(P0.05);NPSLE血清抗GM1 Ig G阳性率和水平与血清抗GM1 Ig M阳性率和水平差异无统计学意义(P0.05)。脑脊液中抗GM1 Ig G、Ig M阳性率,在SLE患者均为52.2%,在正常人均为0.0%,二者之间差异有统计学意义(P0.01);脑脊液中抗GM1 Ig G阳性率,在NPSLE为75.0%,在非-NPSLE为27.3%,二者差异有统计学意义(p0.05);脑脊液中抗GM1 Ig M阳性率,在NPSLE为83.3%,在非-NPSLE为18.2%,二者差异有统计学意义(p0.01);NPSLE脑脊液抗GM1 Ig G阳性率和水平与脑脊液抗GM1 Ig M阳性率和水平差异无统计学意义(P0.05)。结论脑脊液抗GM1抗体检测可能有助于NPSLE的诊断;NPSLE的损害更可能是鞘内局部产生的抗GM1抗体引起,尤其在有中枢神经系统损害的患者;抗GM1抗体可能引起NPSLE患者神经系统脱髓鞘病变。
[Abstract]:Objective to study the clinical diagnostic significance of anti-ganglioside antibody in patients with neuropsychiatric lupus erythematosus (NPSL). Methods 23 patients with systemic lupus erythematosus treated in our hospital from January 2010 to June 2010 were selected as the observation group, including 12 cases of neuropsychiatric lupus erythematosus and 11 cases of non-neuropsychiatric lupus erythematosus (non-NPSLEL). In addition, 10 healthy adults were selected as the control group, and the serum and cerebrospinal fluid (CSF) of the subjects were analyzed and compared. Results the level of anti-GM1 Ig G G M in the control group was significantly different between the patients with systemic lupus erythematosus (SLE) and the normal controls (P 0.01), and the positive rate of anti-GM1 Ig G G M in serum was significantly higher than that in the control group (P < 0.05). There was no significant difference in antibody positive rate and level between NPSLE and non-NPSLE. There was no significant difference in the positive rate and level of anti-GM1 Ig G between NPSLE and anti-GM1 Ig M. There was no significant difference in the positive rate and level of anti-GM1 Ig G and anti-GM1 Ig M between NPSLE and non-NPSLE (P 0.05). The positive rate of anti-GM1 IgG G M in cerebrospinal fluid was 52.2 in SLE and 0.0in normal controls, the difference was statistically significant (P0.01), the positive rate of anti-GM1 Ig G in cerebrospinal fluid was higher than that in SLE, and the positive rate of anti-GM1 Ig G in cerebrospinal fluid was significantly higher than that in normal controls (P < 0.05). The difference between NPSLE and non-NPSLE was statistically significant (p0.05), and the positive rate of anti-GM1 IgG M in cerebrospinal fluid was significantly higher than that in non-NPSLE. The difference between NPSLE and non-NPSLE was statistically significant (p 0.01). The positive rate and level of anti-GM1 Ig G in cerebrospinal fluid of NPSLE were not significantly different from those of CSF anti-GM1 Ig M (P 0.05). Conclusion the detection of anti-GM1 antibody in cerebrospinal fluid may be helpful to the diagnosis of NPSLE and the damage of NPSLE is more likely to be caused by anti-GM1 antibody produced locally in the sheath, especially in patients with central nervous system damage. Anti-GM 1 antibody may cause demyelinating lesions of nervous system in NPSLE patients.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R593.24

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