骨形成指标PINP与骨吸收指标β-CTX在2型糖尿病合并骨质疏松中作用的研究

发布时间：2018-06-16 11:18

本文选题：糖尿病 + 型　；参考：《中国骨质疏松杂志》2017年03期

【摘要】：目的探讨骨形成指标I型胶原氨基端肽原(procollagen type I N-terminal propeptide,PINP)与骨吸收指标β-异构C-端肽(beta-isomerized C-telopeptide,β-CTX)的表达在2型糖尿病(type 2 diabetes,T2DM)合并骨质疏松(osteoprosis,OP)中的意义。方法将118例研究对象按双能X线检测骨密度(bone mineral density,BMD)的检查结果分为3组,骨量正常组41例,骨量减少组42例,骨质疏松组35例。记录其性别、年龄、身高、体重、体质指数(body mass index,BMI)、糖尿病病程等一般基线资料。使用全自动生化分析仪测定空腹血糖(fasting blood glucose,FBG)、血钙(blood calcium,Ca)、血磷(phosphate,P)、血清胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、碱性磷酸酶(alkaline phosphatase,ALP)、甲状旁腺素(parathyroid hormone,PTH)等生化指标,高压液相法测定糖化血红蛋白(Hb A1c),ELISA法检测血清骨形成指标PINP及血清骨吸收指标β-CTX并进行组间比较。结果与骨量正常组比较,骨量减少组与OP组中的PINP、β-CTX均高于正常组(P0.05),与骨量减少组相比,OP组中PINP、β-CTX均高于减少组(P0.05)。股骨颈BMD与年龄、病程、FPG、Hb A1c、β-CTX、PINP呈负相关(r=-0.559、-0.368、-0.255、-0.284、-0.613、-0.314,P0.05),与BMI无明显相关性(P0.05)。结论 T2DM合并OP患者中骨形成与骨吸收均增高,属于高转换性的骨代谢,监测骨代谢标志物PINP与β-CTX,有助于早期诊断及防治T2DM合并OP的发生与发展。
[Abstract]:Objective to investigate the expression of procollagen type N-terminal PINPN and 尾 -isomerized C-telopeptidec (尾 -CTX) in type 2 diabetes mellitus (type 2 diabetes mellitus) with osteoporosis. Methods one hundred and eighteen subjects were divided into 3 groups according to the results of dual-energy X-ray examination: normal bone mass group (41 cases), osteopenia group (42 cases) and osteoporosis group (35 cases). The data of sex, age, height, weight, body mass index (BMI) and diabetes duration were recorded. Automatic biochemical analyzer was used to determine the biochemical parameters such as fasting blood glucose, calcium, serum phosphatee, serum cholesterol total cholesterol, triglyceride-triglyceride, alkaline phosphatase, parathyroid roid, PTH, and so on. Serum bone formation index (PINP) and serum bone resorption index (尾 -CTX) were determined by high pressure liquid chromatography (HPLC) method and compared between groups. Results compared with the normal bone mass group, the PINPand 尾 -CTX in the osteopenia group and op group were higher than those in the normal group, and the PINP and 尾 -CTX levels in the op group were higher than those in the decreased bone mass group. There was a negative correlation between BMD of femoral neck and age, course of disease (FPGG) HbA1c, 尾 -CTX PINP (P < 0.05). There was no significant correlation between BMD of femoral neck and BMI (P 0.05). Conclusion Bone formation and bone resorption are increased in patients with T2DM complicated with op. Monitoring the markers of bone metabolism, PINP and 尾 -CTX, is helpful to the early diagnosis and prevention and treatment of the occurrence and development of OP-associated with T2DM.
【作者单位】：新疆石河子大学医学院第一附属医院内分泌代谢科;新疆石河子大学医学院;
【基金】：石河子大学重大科技攻关计划(gxjs2012-zdgg02-04) 兵团中青年科技创新领军人才专项(2015BC001)
【分类号】：R580;R587.2

【参考文献】