碘131联合甲巯咪唑对甲状腺功能亢进患者骨代谢的影响

发布时间：2018-06-16 21:22

本文选题：碘 + 甲巯咪唑　；参考：《中国现代医学杂志》2017年18期

【摘要】：目的探讨碘131联合甲巯咪唑用于治疗甲亢患者的疗效,分析其对患者骨代谢指标及CXC趋化因子配体10(CXCL10)、CC趋化因子配体22(CCL22)水平的影响。方法选取2013年11月-2015年11月惠州市中心人民医院收治的184例甲亢患者为研究对象,随机分为实验组和对照组,实验组患者给予碘131联合甲巯咪唑进行治疗,对照组患者仅给予甲巯咪唑进行治疗。治疗2个月,对比两组患者的甲状腺功能,骨代谢指标及血清CXCL10、CCL22水平。结果经治疗后两组患者的总三碘甲状腺原氨酸(TT3)、总四碘甲状腺原氨酸(TT_4)、游离三碘甲状腺原氨酸(FT_3)及游离四碘甲状腺原氨酸(TT_4)水平均降低,且实验组低于对照组(P0.05);实验组的治疗总有效率为93.47%,高于对照组(76.1%)(P0.05);经治疗后两组患者的血清降钙素(CT)、骨钙素(BGP)水平降低,实验组低于对照组(P0.05);治疗后,两组患者的PTH水平均升高,实验组高于对照组(P0.05);治疗后两组患者的血清CXCL10、CCL22水平降低,且实验组低于对照组患者(P0.05)。结论小剂量碘131联合甲巯咪唑治疗甲状腺功能亢进患者能够有效改善患者的甲状腺功能及骨代谢情况,调节Th1/Th2细胞的失衡,降低CXCL10、CCL22表达水平,改善患者的临床状况。
[Abstract]:Objective to investigate the effect of iodine 131 combined with methimazole in the treatment of hyperthyroidism and its effect on bone metabolism and CCL22 level of CXC chemokine ligand 10CXCL10C. Methods 184 patients with hyperthyroidism admitted in Huizhou Central people's Hospital from November 2013 to November 2015 were randomly divided into experimental group and control group. Patients in the control group were treated with methimazole only. After 2 months of treatment, the thyroid function, bone metabolism and serum CXCL10 CCL22 levels were compared between the two groups. Results after treatment, the levels of total triiodothyronine (TT3), total tetraiodothyronine (TT4), free triiodothyronine (FT3) and free tetraiodothyronine (TT4) were decreased in both groups. The experimental group was lower than the control group (P 0.05), the total effective rate of the experimental group was 93.47, which was higher than that of the control group (76.1%), the serum levels of calcitonin, osteocalcin (BGP) in the two groups were lower than those in the control group (P 0.05), the levels of PTH in the two groups were increased after treatment. The levels of serum CXCL10 and CCL22 in the experimental group were lower than those in the control group, and the level of CCL22 in the experimental group was lower than that in the control group. Conclusion low dose iodine 131 combined with methimazole can effectively improve the thyroid function and bone metabolism of patients with hyperthyroidism, regulate the imbalance of Th1 / Th2 cells, decrease the expression level of CCL22 in CXCL10, and improve the clinical status of patients with hyperthyroidism.
【作者单位】：广东省惠州市中心人民医院核医学科;
【分类号】：R581.1

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